Results 81 to 90 of about 1,886,041 (292)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Physical Work Environment in relation to the Physical and Psychological Symptoms of Sick Building Syndrome [PDF]

, 2011
This study investigated the relationship between perceptions of a poor physical work environment (PWE) and sick building syndrome (SBS), and with various psychological variables that impact organizational productivity.
Meikle, Sarah Marie
core  

Affective incoherence: when affective concepts and embodied reactions clash. [PDF]

, 2009
In five studies, the authors examined the effects on cognitive performance of coherence and incoherence between conceptual and experiential sources of affective information.
Centerbar, David B., Clore, Gerald L., Garvin, Erika D., Schnall, Simone   +3 more
core   +2 more sources

Affective temperament and mood spectrum symptoms in workers suffering from work-related stress disorders

, 2022
Adjustment Disorders (AD) which develop in response to work-related stressors represent a model of psychiatric occupational disease. Major Depressive Episodes (MDE) although often associated to work-related stressors are unlikely recognized by insurance ...
Foddis, Rudy, Chiumiento, Martina, Caldi, Fabrizio, Veltri, Antonello, Guglielmi, Giovanni, Carmassi, Claudia, Corsi, Martina, Baldanzi, Sigrid, Dell'Osso, Liliana, Buselli, Rodolfo, Marino, Riccardo, Cristaudo, Alfonso   +11 more
core   +1 more source

Plasma Neurofilament Light and p-tau181 and Risk of Psychosis in Parkinson’s Disease

Journal of Parkinson’s Disease, 2022
Background: Neuropsychiatric symptoms are common and important to people with Parkinson’s disease (PD), but their etiology is poorly understood. Plasma neurofilament light (NfL) and p-tau181 are biomarkers of neuro-axonal degeneration and tau pathology ...
Lucy L. Gibson, Thomas A. Pollak, Amanda Heslegrave, Abdul Hye, Lucia Batzu, Silvia Rota, Dhaval Trivedi, Timothy R. Nicholson, Dominic ffytche, Henrik Zetterberg, K. Ray Chaudhuri, Dag Aarsland   +11 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring [PDF]

, 2009
Background Adverse effects of maternal substance use during pregnancy on fetal development may increase risk of psychopathology. Aims To examine whether maternal use of tobacco, cannabis or alcohol during pregnancy increases risk of offspring ...
David Gunnell, Dieter Wolke, Jeremy Horwood, Kate Thomas, Andrew Thompson, Gunnell, David, Lewis, Glyn, Harrison, Glynn, Stanley Zammit, Paulo Menezes, Hollis, Chris, Glyn Lewis, Wolke, Dieter, Zammit, Stanley, Horwood, Jeremy, Thomas, Kate, Thompson, Andrew D., Menezes, Paulo, Chris Hollis, Glynn Harrison, Thompson, Andrew   +20 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Beyond diagnosis: symptom patterns across complex PTSD and borderline personality disorder

Frontiers in Psychiatry
BackgroundComplex post-traumatic stress disorder (cPTSD) and borderline personality disorder (BPD) share overlapping clinical features, complicating accurate diagnosis and treatment. This overlap has fueled ongoing discussions regarding whether cPTSD and
Joe J. Simon, Joe J. Simon, Kristin Spiegler, Kadiatou Coulibaly, Marion A. Stopyra, Marion A. Stopyra, Hans-Christoph Friederich, Hans-Christoph Friederich, Oliver Gruber, Christoph Nikendei   +9 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source