Results 111 to 120 of about 7,128,463 (355)

Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect

open access: yesBrain Sciences, 2019
Allosteric modulators of metabotropic glutamate 5 receptors (mGlu5 receptors) have been identified as a promising treatment to independently alleviate both negative affective states and ethanol-seeking and intake.
Chelsea R. Kasten   +2 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

The Clinical Features of Paranoia in the 20th Century and Their Representation in Diagnostic Criteria From DSM-III Through DSM-5 [PDF]

open access: yes, 2016
This review traces, through psychiatric textbooks, the history of the Kraepelinian concept of paranoia in the 20th century and then relates the common reported symptoms and signs to the diagnostic criteria for paranoia/delusional disorder in DSM-III ...
Kendler, Kenneth S.
core   +2 more sources

Making Sense of Emotions and Affective Investments in War: RT and the Syrian Conflict on YouTube

open access: yesMedia and Communication, 2019
Within the context of an ‘affective turn’ in media studies and the social sciences, this article explores the methodological challenges of researching emotions when studying online videos of conflict.
Precious N. Chatterje-Doody   +1 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Trust and the Decision to Outsource: Affective Responses and Cognitive Processes [PDF]

open access: yes
Many of the various forms of cooperative strategy that firms are pursuing in today's economy entail the placing of important business functions in the hands of a partner.
Hansen, Mark H., Morrow, J.L., Jr.
core   +1 more source

Affect: knowledge, communication, creativity and emotion [PDF]

open access: yes, 2008
Concerns about emotional well-being have recently become the focus of social policy, particularly in education settings. This is a sudden and unique development in placing new ideas about emotion and creativity and communication in curriculum content ...
Ecclestone, Kathryn, Hayes, Dennis
core   +1 more source

Extended emotions [PDF]

open access: yes, 2016
Until recently, philosophers and psychologists conceived of emotions as brain- and body-bound affairs. But researchers have started to challenge this internalist and individualist orthodoxy.
Krueger, Joel, Szanto, Thomas
core   +2 more sources

Towards a New Epistemology: The "Affective Turn"

open access: yes, 2012
– what Patricia Clough has identified as an “affective turn” in the humanities and social sciences – draws on some of the most innovative and productive theoretical and epistemological trends of the two last decades of the twentieth century ...
A. Athanasiou   +2 more
semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

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