Results 131 to 140 of about 67,366 (312)
Scheler on shame: a critical review [PDF]
, 2017 This paper presents a critical review of Scheler’s analysis of shame's structure, dynamic, and affectivity, and his explanation of phenomena of shame. This first part of the paper examines Scheler’s accounts of shame’s basic condition, the law ultimately
Dahlstrom, Daniel O.
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Journal of Neurology, Neurosurgery & Psychiatry, 1956 A, HARRIS, M, METCALFE
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Bergson and Technical Creativity
BergsonianaBergson portrays technics as a central expression of human creativity, but he also describes it as degenerating, mechanistic instrumentality. Can technics be truly creative or is it bound to the mechanistic processes of matter? In this paper, I develop a
Julius Telivuo
doaj +1 more source
LIGHT AND AFFECTS FROM A COMPARATIVE POINT OF VIEW [PDF]
, 2014 Light metaphors occurring in Chinese philosophy and Stoicism are of special interest for the unique ways they channel potentialities of the self. In this paper I apply ideas from cognitive linguistics to examine selected structural features of these ...
Takaki, Kyle
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The boundaries of affectivity (and a coda on extended consciousness)
Perspectiva FilosóficaIn this contribution I will offer a rough guide through “situated affectivity”,a small galaxy of theories, ideas, intuitions which are recently growing atthe boundaries between philosophy of emotion, philosophy of mind, philo-sophy of cognitive science ...
Giulia Piredda
doaj +1 more source