Results 71 to 80 of about 11,506 (266)
Valenciana, 2020 La vejez constituye una de las etapas de la vida humana menos estudiada de forma sistemática por la filosofía. Recién en los últimos años, han aparecido más trabajos en torno a la vejez, debido probablemente a los nuevos desafíos éticos, sociales ...
Diana Aurenque Stephan
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Derecho al matrimonio y diversidad familiar = Right to marriage and family diversity
Revista de Derecho Político, 2013 El reconocimiento del matrimonio entre personas del mismo sexo constituye un avance en la garantía de la dignidad de la persona y del libre desarrollo de la personalidad.
Octavio Salazar Benítez
doaj +1 more source
Avatar affectivity and affection
Transformations, 2018 Avatars and gamers create channels of affective flow through their connection to a gameworld. Elsewhere (Wilde and Evans) I have explored this flow as an empathic exchange, wherein the desires of each must be aligned with the other in order to progress in-game.
openaire +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Revista Internacional de Ciencias del Deporte, 2015 El perfeccionismo en la adolescencia ha sido asociado a altos niveles de desajuste y trastorno psicológico y bajos niveles de bienestar subjetivo y ajuste psicológico.
Antonio Méndez-Giménez +2 more
doaj +1 more source