Results 81 to 90 of about 1,379 (241)

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

A quad‐cistronic fluorescent biosensor system for real‐time detection of subcellular Ca2+ signals

British Journal of Pharmacology, EarlyView.
Background and Purpose The calcium ion (Ca2+) is a versatile cellular messenger regulating a variety of biological processes. Compounds modulating subcellular Ca2+ signals hold substantial pharmacological potential. Advances in fluorescent biosensors have revolutionised Ca2+ imaging.
Anna Lischnig, Yusuf C. Erdoğan, Benjamin Gottschalk, Michael Gruber, Andrea Groselj‐Strele, Sandra Burgstaller, Wolfgang F. Graier, Roland Malli   +7 more
wiley   +1 more source

Randomised, phase 1 evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of iptacopan in healthy volunteers

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva, Guido Junge, Kenneth Kulmatycki, Robert Schmouder, Anna Schubart, Marie‐Anne Valentin   +5 more
wiley   +1 more source

Logarithmic bounds for Roth's theorem via almost-periodicity

Discrete Analysis, 2019
Logarithmic bounds for Roth's theorem via almost-periodicity, Discrete Analysis 2019:4, 20pp. A central result of additive combinatorics, Roth's theorem, asserts that for every $\delta>0$ there exists $N$ such that every subset of $\{1,2,\dots,N\}$ of ...
Thomas Bloom, Olof Sisask
doaj   +1 more source

Splatshop: Efficiently Editing Large Gaussian Splat Models

Computer Graphics Forum, EarlyView.
Abstract We present Splatshop, a highly optimized toolbox for interactive editing (selection, deletion, painting, transformation, …) of 3D Gaussian Splatting models. Utilizing a comprehensive collection of heuristic approaches, we carefully balance between exact and fast rendering to enable precise editing without sacrificing real‐time performance. Our
Markus Schütz, Christoph Peters, Florian Hahlbohm, Elmar Eisemann, Marcus Magnor, Michael Wimmer   +5 more
wiley   +1 more source

The prediction of projectile-target intersection for moving tank based on adaptive robust constraint-following control and interval uncertainty analysis

Defence Technology
To improve the hit probability of tank at high speed, a prediction method of projectile-target intersection based on adaptive robust constraint-following control and interval uncertainty analysis is proposed.
Cong Li, Xiuye Wang, Yuze Ma, Fengjie Xu, Guolai Yang   +4 more
doaj   +1 more source

Characterisation of steady‐state pharmacokinetics and glucodynamics of once‐weekly insulin efsitora alfa in individuals with type 2 diabetes

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To evaluate the steady‐state pharmacokinetics (PK) and glucodynamic effects of insulin efsitora alfa (efsitora) over a weekly interval in adults with type 2 diabetes (T2D). Materials and Methods This open‐label, multiple dose, euglycaemic clamp study was conducted in 56 insulin naïve adults with T2D (mean [±SD] age, 61.9 ± 5.98 years ...
Jennifer Leohr, Oliver Klein, Tim Heise, Eric Zijlstra, Juliana M. Bue‐Valleskey, Subha Suriyapperuma, Ryan Jarrett, Douglas James, Micheal Case, David Waters, Edward Pratt, Helle Linnebjerg   +11 more
wiley   +1 more source

Affine Invariance of Bézier Curves on Digital Grid

Mathematics
Affine invariance is one of the most fundamental properties of free-form curves, ensuring that transformations such as translation, scaling, rotation, and shearing preserve the essential characteristics of the geometric shape.
Miklós Hoffmann, Ede Troll
doaj   +1 more source

On models of affine arithmetic

By affine arithmetic is meant the set of affine consequences of Peano arithmetic. This is a continuous theory which is studied in the framework of affine logic, a sublogic of continuous logic. Affine arithmetic is undecidable. Also, its models are generally lattice ordered and carry a nontrivial metric.
openaire   +2 more sources

Kant's Dialectic of Enlightenment

European Journal of Philosophy, EarlyView.
Abstract Kant's moral thought emphasizes both our ability to make adequate, immediate moral judgment, as well as our deep‐seated forms of self‐entrapment. Strikingly, these forms of self‐entrapment are not simply the result of reason being overpowered by forces external to it, but arise out of reason itself, as pathological versions of otherwise ...
Laurenz Ramsauer
wiley   +1 more source