Results 41 to 50 of about 6,039 (296)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Sparse Adaptive Channel Estimation Based on lp-Norm-Penalized Affine Projection Algorithm
International Journal of Antennas and Propagation, 2014 We propose an lp-norm-penalized affine projection algorithm (LP-APA) for broadband multipath adaptive channel estimations. The proposed LP-APA is realized by incorporating an lp-norm into the cost function of the conventional affine projection algorithm (
Yingsong Li +4 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Improving Performance of Affine Projection–Like Algorithm Using Two Combination Methods
Journal of Applied MathematicsThe affine projection–like (APL) algorithm has garnered significant attention due to its low steady-state mean-square deviation and simplicity. However, its performance is limited by a fixed step-size, which forces a trade-off between fast convergence ...
Yinxia Dong +6 more
doaj +1 more source
IEEE Access, 2017 The individual-activation-factor memory proportionate affine projection algorithm (IAF-MPAPA) provides a good solution for echo cancelation. However, the IAF-MPAPA with fixed regularization factor requires a tradeoff between fast convergence rate and low
Tao Zhang, Hai-Quan Jiao, Zhi-Chun Lei
doaj +1 more source
Alternating Adaptive Beamforming System Based on the APL/SR-LMS Algorithms
Revista Elektrón, 2022 Beamforming is a wireless communication technique used in telecommunications applications, which is used to separate a desired signal from interfering signals.
Jesús Roberto del Ángel Ruíz +4 more
doaj +1 more source
Pseudo affine projection sign algorithm for robust system identification
, 2018 A pseudo affine projection sign algorithm is proposed in which the weighted taxicab norm is minimised as the cost function and an approximation technique is applied according to the Gauss-Seidel method.
Kim, SW, Ban, SJ
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Multichannel Filtered-X Error Coded Affine Projection-Like Algorithm with Evolving Order
Shock and Vibration, 2017 Affine projection (AP) algorithms are commonly used to implement active noise control (ANC) systems because they provide fast convergence. However, their high computational complexity can restrict their use in certain practical applications.
J. G. Avalos +4 more
doaj +1 more source