Results 51 to 60 of about 152,745 (261)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Fusion and braiding in finite and affine Temperley-Lieb categories

, 2016
Finite Temperley-Lieb (TL) algebras are diagram-algebra quotients of (the group algebra of) the famous Artin's braid group $B_N$, while the affine TL algebras arise as diagram algebras from a generalized version of the braid group.
Gainutdinov, A. M., Saleur, H.
core   +2 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Horizon temperature on the real line

Physics Letters B, 2019
We illustrate the analogue of the Unruh effect for a quantum system on the real line. Our derivation relies solely on basic elements of representation theory of the group of affine transformations without a notion of time or metric. Our result shows that
Michele Arzano, Jerzy Kowalski-Glikman
doaj   +1 more source

Triangular Regions Representations for Matching Images With Viewpoint Changes

IEEE Access, 2022
This paper proposes triangular region representations based on keypoints detected in images with viewpoint changes. The strongest keypoints in the reference and query images are allocated individually using a previously published contourlet-based ...
Ibrahim El Rube', Sameer Alsharif
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Double affine Lie algebras and finite groups

, 2009
We introduce and begin to study Lie theoretical analogs of symplectic reflection algebras for a finite cyclic group, which we call "cyclic double affine Lie algebra". We focus on type A : in the finite (resp.
Guay, Nicolas, Hernandez, David, Loktev, Sergey   +2 more
core   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Singularities of nilpotent Slodowy slices and collapsing levels of W-algebras

Forum of Mathematics, Sigma
We develop techniques to construct isomorphisms between simple affine W-algebras and affine vertex algebras at admissible levels. We then apply these techniques to obtain many new, and conjecturally all, admissible collapsing levels for affine W-algebras.
Tomoyuki Arakawa, Jethro van Ekeren, Anne Moreau   +2 more
doaj   +1 more source

A Method for Determining the Affine Equivalence of Boolean Functions

IEEE Access, 2019
Determining the affine equivalence of Boolean functions has significant applications in circuit and cryptography. Previous methods for determining this require a large amount of computation when Boolean functions are bent functions or when the truth ...
Ziyu Wang, Xiao Zeng, Jinzhao Wu, Guowu Yang   +3 more
doaj   +1 more source