Results 61 to 70 of about 152,745 (261)
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
Biorthogonal-Wavelet-Based Method for Numerical Solution of Volterra Integral Equations
Entropy, 2019 Framelets theory has been well studied in many applications in image processing, data recovery and computational analysis due to the key properties of framelets such as sparse representation and accuracy in coefficients recovery in the area of numerical ...
Mutaz Mohammad
doaj +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
A new framework for the unification of fundamental physics - Affine connection representation of gauge fields [PDF]
, 2021 Zhao-Hui MAN
openalex +3 more sources
MMAR-Net: A Multi-Stride and Multi-Resolution Affine Registration Network for CT Images
Big Data Mining and AnalyticsThe evolution of lung lesions can be assessed by examining multiple CT screenings, which needs to align two CT images accurately. In this study, we propose a multi-stride and multi-resolution affine registration network, called MMAR-net, for 3D affine ...
Fu Zhou +4 more
doaj +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Hypergeometric τ Functions of the q-Painlevé Systems of Type (A_2+A_1)^{(1)}
Symmetry, Integrability and Geometry: Methods and Applications, 2010 We consider a q-Painlevé III equation and a q-Painlevé II equation arising from a birational representation of the affine Weyl group of type (A_2+A_1)^{(1)}. We study their hypergeometric solutions on the level of τ functions.
Nobutaka Nakazono
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Entropy, 2016 We introduce the symplectic structure of information geometry based on Souriau’s Lie group thermodynamics model, with a covariant definition of Gibbs equilibrium via invariances through co-adjoint action of a group on its moment space, defining physical ...
Frédéric Barbaresco
doaj +1 more source