Results 41 to 50 of about 243,977 (284)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Orlicz Mean Dual Affine Quermassintegrals
Journal of Function Spaces, 2018 Our main aim is to generalize the mean dual affine quermassintegrals to the Orlicz space. Under the framework of dual Orlicz-Brunn-Minkowski theory, we introduce a new affine geometric quantity by calculating the first Orlicz variation of the mean dual ...
Chang-Jian Zhao, Wing-Sum Cheung
doaj +1 more source
DCTM: Discrete-Continuous Transformation Matching for Semantic Flow
, 2017 Techniques for dense semantic correspondence have provided limited ability to deal with the geometric variations that commonly exist between semantically similar images.
Kim, Seungryong +3 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Nekrasov's Partition Function and Refined Donaldson-Thomas Theory: the Rank One Case
Symmetry, Integrability and Geometry: Methods and Applications, 2012 This paper studies geometric engineering, in the simplest possible case of rank one (Abelian) gauge theory on the affine plane and the resolved conifold.
Balázs Szendrői
doaj +1 more source
Adaptable nonlinear bimode metamaterials with rigid bars, pivots, and actuators
, 2012 A large family of periodic planar non-linear bimode metamaterials are constructed from rigid bars and pivots. They are affine materials in the sense that their macroscopic deformations are only affine deformations: at large distances any deformation must
Milton, Graeme Walter
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Locally linear attributes of ReLU neural networks
Frontiers in Artificial Intelligence, 2023 A ReLU neural network functions as a continuous piecewise linear map from an input space to an output space. The weights in the neural network determine a partitioning of the input space into convex polytopes, where each polytope is associated with a ...
Ben Sattelberg +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
On the Non Metrizability of Berwald Finsler Spacetimes
Universe, 2020 We investigate whether Szabo’s metrizability theorem can be extended to Finsler spaces of indefinite signature. For smooth, positive definite Finsler metrics, this important theorem states that, if the metric is of Berwald type (i.e., its Chern–Rund ...
Andrea Fuster +3 more
doaj +1 more source