Results 71 to 80 of about 243,977 (284)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Affine Differential Invariants of Functions on the Plane

Journal of Applied Mathematics, 2013
A differential invariant is a function defined on the jet space of functions that remains the same under a group action. It is an important concept to solve the equivalence problem.
Yuanbin Wang, Xingwei Wang, Bin Zhang
doaj   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Cosmological solutions in polynomial affine gravity with torsion

European Physical Journal C: Particles and Fields
The Polynomial Affine Gravity is an alternative gravitational model, where the interactions are mediated solely by the affine connection, instead of the metric tensor.
Oscar Castillo-Felisola, Bastian Grez, Gonzalo J. Olmo, Oscar Orellana, José Perdiguero Gárate   +4 more
doaj   +1 more source

One-dimensional packaging with method of modified ant colony [PDF]

BIO Web of Conferences
The study explores the use of the ant algorithm for solving one-dimensional packing problems. It discusses the structure of the decision search graph, the search process on the graph, methods of pheromone deposition and evaporation.
Ganzhur M. A.
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Reproducing Kernel Hilbert Space and Coalescence Hidden-variable Fractal Interpolation Functions

Demonstratio Mathematica, 2019
Reproducing Kernel Hilbert Spaces (RKHS) and their kernel are important tools which have been found to be incredibly useful in many areas like machine learning, complex analysis, probability theory, group representation theory and the theory of integral ...
Prasad Srijanani Anurag
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

A Robust and Efficient Algorithm for Tool Recognition and Localization for Space Station Robot

International Journal of Advanced Robotic Systems, 2014
This paper studies a robust target recognition and localization method for a maintenance robot in a space station, and its main goal is to solve the target affine transformation caused by microgravity and the strong reflection and refraction of sunlight ...
Lingbo Cheng, Zhihong Jiang, Hui Li, Qiang Huang   +3 more
doaj   +1 more source