Results 91 to 100 of about 1,578,929 (319)

HELIN Acquisitions Affinity Group minutes for 3/23/12

, 2012
Minutes of the Acquisitions Affinity Group of the HELIN Consortium for March ...
HELIN Consortium. Acquisitions Affinity Group
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

CSF Aquaporin-4 levels in controls and in idiopathic normal pressure hydrocephalus before and after shunt surgery

Fluids and Barriers of the CNS
Background Aquaporin-4 (AQP4) is crucial for brain fluid regulation and glymphatic system function. Idiopathic normal pressure hydrocephalus (INPH) is characterized by impaired CSF flow and is treated with shunt surgery.
Johan Eriksson De Ryst, Sofia Bergström, Sara Mravinacova, David Bäckström, Sara Qvarlander, Anna Månberg, Anders Eklund, Jan Malm   +7 more
doaj   +1 more source

HELIN Serials Affinity Group minutes for 03/06/12

, 2012
Minutes of the Serials Affinity Group of the HELIN Consortium for March ...
HELIN Consortium. Serials Affinity Group
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Antibody Fragments and Their Purification by Protein L Affinity Chromatography

Antibodies, 2015
Antibodies and related proteins comprise one of the largest and fastest-growing classes of protein pharmaceuticals. A majority of such molecules are monoclonal antibodies; however, many new entities are antibody fragments.
Gustav Rodrigo, Mats Gruvegård, James M. Van Alstine   +2 more
doaj   +1 more source

HELIN Cataloging Affinity Group minutes for 12/08/10

, 2010
Minutes of the Cataloging Affinity Group of the HELIN Consortium for December ...
HELIN Consortium. Cataloging Affinity Group
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Affine Cones as Images of Affine Spaces

Proceedings of the Steklov Institute of Mathematics
We prove that an affine cone $X$ admits a surjective morphism from an affine space if and only if $X$ is unirational.
openaire   +3 more sources

HELIN Cataloging Affinity Group minutes for 12/20/11

, 2011
Minutes of the Cataloging Affinity Group of the HELIN Consortium for December ...
HELIN Consortium. Cataloging Affinity Group
core