Results 101 to 110 of about 1,578,929 (319)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Cheating the Hunger Games; Mechanisms Controlling Clonal Diversity of CD8 Effector and Memory Populations

Frontiers in Immunology, 2018
Effector and memory CD8 T cells have an intrinsic difference in the way they must approach antigen; effector cells need to address the pathogen at hand and therefore favor outgrowth of only high-affinity clones. In contrast, the memory pool benefits from
Inga Kavazović, Bojan Polić, Felix M. Wensveen, Felix M. Wensveen   +3 more
doaj   +1 more source

HELIN Cataloging Affinity Group minutes for 03/28/11

, 2011
Minutes of the Cataloging Affinity Group of the HELIN Consortium for March ...
HELIN Consortium. Cataloging Affinity Group
core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Fontenelle et la chimie : la recherche d’une « loi fondamentale » pour la chimie

Methodos, 2012
In this paper, my aim is to reexamine Fontenelle’s position as to chemistry. Before he became the Secretary of the Académie Royale des Sciences of Paris, Fontenelle knew chemistry quite badly and he ridiculed it in his personal works; but as the ...
Luc Peterschmitt
doaj   +1 more source

HELIN Consortium. Digital Collections Affinity Group

, 2011
Minutes of the Digital Collections Affinity Group of the HELIN Consortium forApril ...
HELIN Digital Collections Affinity Group minutes for
core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

HELIN Cataloging Affinity Group minutes for 10/26/10

, 2010
Minutes of the Cataloging Affinity Group of the HELIN Consortium for October ...
HELIN Consortium. Cataloging Affinity Group
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

HELIN Acquisitions Affinity Group minutes for 9/30/10

, 2010
Minutes of the Acquisitions Affinity Group of the HELIN Consortium for September ...
HELIN Consortium. Acquisitions Affinity Group
core