Results 251 to 260 of about 2,190,614 (293)

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

Advanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth A. Wilson, Harrison L. Baker, Mikayla Hady, Nadja Maldonado Luna, Gregor Bieri, Saul A. Villeda, Lisa M. Ellerby, Birgit Schilling, Tamara Alliston   +15 more
wiley   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

Advanced Science, EarlyView.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li, Shu‐Min Xu, Xin‐Chen Jiang, Le‐Tian Dai, Yu‐Tao Hu, Kai‐Bo Wang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuo‐Bin Chen   +8 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Deciphering Protein Corona by scFv-Based Affinity Chromatography.

Nano letters (Print), 2021
It remains challenging to precisely decipher the structural and functional characteristics of protein coronas. To overcome the drawbacks frequently occurring in the traditional separation methods, an anti-PEG single-chain variable fragment (PEG-scFv ...
Yuxiu Chu, Wenjing Tang, Zui Zhang, Cheng Li, Jun Qian, Xiaoli Wei, T. Ying, Weiyue Lu, Changyou Zhan   +8 more
semanticscholar   +1 more source

Metal chelate affinity chromatography, a new approach to protein fractionation

Nature, 1975
J. Porath, J. Carlsson, I. Olsson, Greta Belfrage   +3 more
semanticscholar   +3 more sources

Twin-column CaptureSMB: a novel cyclic process for protein A affinity chromatography.

Journal of Chromatography A, 2015
M. Angarita, T. Müller-Späth, Daniel Baur, Roel Lievrouw, G. Lissens, M. Morbidelli   +5 more
semanticscholar   +3 more sources

Recent advances in bio‐affinity chromatography for screening bioactive compounds from natural products

Journal of Pharmaceutical and Biomedical Analysis, 2019
HighlightsBio‐affinity chromatography (BAC) showed a great potential in natural products screening.An overview of the BAC and its applications for natural products screening was presented.Current reported BAC stationary phases for natural products ...
Jialiang Guo, Hang Lin, Jincai Wang, Yuanjing Lin, Tingting Zhang, Zhengjin Jiang   +5 more
semanticscholar   +1 more source

Applications of aptamer affinity chromatography

TrAC - Trends in Analytical Chemistry, 2012
Qiang Zhao, Minghuo Wu, X. Le, Xing-Fang Li   +3 more
semanticscholar   +3 more sources

affinity chromatography

Catalysis from A to Z, 2020
J. Xu
semanticscholar   +1 more source