Results 21 to 30 of about 8,457 (258)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
O multiculturalismo e a dialética do universal e do particular
Estudos Avançadosresumo Após a Revolução Francesa de 1789 o Estado democrático estabeleceu os direitos universais do cidadão. Os movimentos sociais, inicialmente, encamparam esse ideal universalista e lutaram pelo reconhecimento de seus direitos: as mulheres obtiveram o ...
CELSO FREDERICO
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers +7 more
wiley +1 more source
Mujeres, acciones afirmativas y capacidades humanas
EleutheraThis article seeks to determine argumentative elements within the discussions of feminist studies. Mainly, regarding the scope of affirmative actions, the theory of human capabilities and the internationalist feminism of ...
Luz Mireya Mendieta Pineda +2 more
doaj +1 more source
O Globo and the racial quotas: an analysis of the newspaper editorials (2003 - 2012)
Revista Eletrônica História em Reflexão, 2017 This paper consists on an analysis of newspaper editorials from O Globo on the issue of racial affirmative actions in the access towards public universities in Brazil.
Matheus de Carvalho Leibão
doaj +1 more source
A measurement perspective on affirmative action in U.S. medical education [PDF]
Medical Education Online, 2013 Background: The U.S. Supreme Court has recently heard another affirmative action case, and similar programs to promote equitable representation in higher education are being debated and enacted around the world.
Clarence D. Kreiter
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li +11 more
wiley +1 more source
A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi +17 more
wiley +1 more source
Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier +6 more
wiley +1 more source
Affirmative action and social stereotypes: Deconstructing the myth of minority inferiority
Education Policy Analysis Archives, 2019 Affirmative action aimed at promoting access for groups considered minority to universities are important for combating structural inequalities and promoting social justice.
Eloisio Moulin de Souza
doaj +1 more source