Results 141 to 150 of about 161,873 (306)

Mass‐Produced and High‐Performance Nanowell Biosensor Fabricated via Semiconductor Manufacturing for Rapid and Accurate COVID‐19 Diagnosis in the Clinical Field

Advanced Science, EarlyView.
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park, Zahra Rezaei, Nam Ho Bae, Donggee Rho, Da‐Seul Kim, EunYoung Go, YoungTae Seo, Seok Jae Lee, Won Chan Seo, Luke P. Lee, HeaYeon Lee, Su Ryon Shin   +11 more
wiley   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

A Scalable BaTiO3 Nanocoating Strategy for Cost‐Effective and Stable Sulfide‐Based All‐Solid‐State Batteries

Advanced Science, EarlyView.
A rapid and scalable 10 min BaTiO3 (BTO) nanocoating uniformly encapsulates Li‐P‐S‐X sulfide electrolytes, serving as a dielectric “shield” that enhances air stability, reduces cost, and mitigates interfacial degradation. This multifunctional coating enables fast‐charging, durable all‐solid‐state batteries with ultralong cycling stability (>10 000 ...
Wenjin Li, Qingmei Xiao, Shiming Huang, Ruonan Zhang, Hong Yu, Donghao Liang, Kaiyuan Deng, Cheng Liu, Beisen Chen, Puxi An, Guangliang Gary Liu   +10 more
wiley   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

A ACESSIBILIDADE SOB O ENFOQUE ÉTICO NA CONTABILIDADE

Revista Ambiente Contábil, 2012
A desigualdade está cada dia mais presente no cotidiano causando a exclusão de muitas pessoas do mercado de trabalho em virtude de características físicas.
Jonatas Dutra Sallaberry, Bárbara Rocha Bittencourt Sallaberry   +1 more
doaj  

Diffusion Characteristics of Ru and Oxygen Vacancies in Ta2O5 for Resistive Random Access Memory Devices: A Density Functional Theory Investigation

Advanced Electronic Materials, EarlyView.
Atomistic analysis of ruthenium (Ru) and oxygen vacancy (OV) diffusion in Ta₂O₅‐based memristors is performed. DFT calculations demonstrate interstitial Ru in Ta₂O₅ has lower diffusion barriers and formation energies than OVs, enhancing mobility and stability.
Md. Sherajul Islam, Sabyasachi Ganguli, J. Joshua Yang, Ajit K Roy   +3 more
wiley   +1 more source

Sex and rank in public service hierarchies: Rank distribution in Ghana's health and security services. [PDF]

PLoS One
Norman ID, Kpeglo ED, Nadarajah S.
europepmc   +1 more source

Wine Tourism as a Catalyst for Sustainable Performance: The Mediating Role of Corporate Legitimacy and Green Innovation

Agribusiness, EarlyView.
ABSTRACT This study aims to explore the influence of Wine Tourism (WT) on the Sustainable Performance (SP) of wineries in Spain. It particularly investigates how Corporate Social Legitimacy (CSL) and Green Innovation (GI) may act as intermediary factors in this relationship.
Javier Martínez‐Falcó, Eduardo Sánchez‐García, Bartolomé Marco‐Lajara, Luis A. Millán‐Tudela   +3 more
wiley   +1 more source