A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints
Advanced Science, EarlyView.ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu +3 more
wiley +1 more source
Evaluating the phylogenetic signal of morphosyntax. [PDF]
Pozn Stud Contemp LinguistSleeman R +6 more
europepmc +1 more source
A Reconfigurable Memristive Spiking Neuron Enabling Advanced Neuromorphic Computing
Advanced Science, EarlyView.Pek Jun Tiw and co‐workers develop a reconfigurable memristive neuron that can exhibit four spiking behaviors with freely tunable spike train parameters. The neuron supports multiplexed spike encoding of multiple pieces of information. It also supports advanced neural network strategies, such as neural heterogeneity and dynamic mode switching ...
Pek Jun Tiw +6 more
wiley +1 more source
Protocol for non-invasive pulsed-Doppler evaluation of blood flow in the mouse ophthalmic artery. [PDF]
STAR ProtocAwad R, Martin E, Reddy AK, Sharina I.
europepmc +1 more source
A Magnetic‐Driven Self‐Rotation‐Stabilized Miniature Swimming Robot
Advanced Science, EarlyView.Inspired by the stable rotational descent of seeds in nature, this study designs a magnetic‐driven self‐rotation‐stabilized miniature swimming robot (MSMSR). Based on a resonance‐driven strategy, the robot exhibits high swimming performance, offering enhanced directional swimming and improved resistance to water flow disturbances compared to existing ...
Fujun Wang +4 more
wiley +1 more source
T-Graft for Single Stage Laryngotracheal Reconstruction: Revisiting a Previously Described Technique. [PDF]
Laryngoscope Investig OtolaryngolKlimara MJ +3 more
europepmc +1 more source
Advanced Science, EarlyView.An electronics‐free smart scleral lens passively monitors dry eye disease‐related tear biomarkers through colorimetric sensing of chloride, pH, and ocular surface temperature. Smartphone‐assisted image analysis enables quantitative interpretation, providing a simple, non‐invasive strategy for ocular health monitoring without integrated electronics ...
Ziheng Wang +15 more
wiley +1 more source
Tibial Tubercle Osteotomy With Medial Patellofemoral Ligament Reconstruction Utilizing Autograft Hamstring Tendon and Knotless Suture Anchor Fixation. [PDF]
Video J Sports MedWinzenried AE +4 more
europepmc +1 more source
Advanced Science, EarlyView.Freestanding hierarchical‐porous BCZT thin films integrate a compliant porous surface with a dense piezoceramic backbone to balance mechanical reliability, voltage sensitivity, and acoustic coupling. The films enable stable wearable pulse‐wave monitoring and enhanced tissue‐coupled ultrasonic energy harvesting, offering a promising route toward soft ...
Zifan Li +14 more
wiley +1 more source
A metallophotoredox strategy for biocatalytic radical C-N<sub>3</sub> and C-SCN bond formatio. [PDF]
Methods EnzymolRui J, Mu X, Huang X.
europepmc +1 more source