Results 11 to 20 of about 461 (138)
Clinical Evaluation of the Effect of Aficamten on QT/QTc Interval in Healthy Participants [PDF]
Clinical and Translational ScienceAficamten is a next‐in‐class, small‐molecule, cardiac myosin inhibitor in development for treating hypertrophic cardiomyopathy (HCM). This 2‐part study evaluated aficamten's impact on QTc interval in healthy participants.Neha Maharao, Donghong Xu, Tyrell J. Simkins, Owen Bowles, Genzhou Liu, Youcef Benattia, Adrienne Griffith, Stephen B. Heitner, Stuart Kupfer, Polina German +9 moredoaj +5 more sourcesSafety and Efficacy of Mavacamten and Aficamten in Patients With Hypertrophic Cardiomyopathy [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Cardiac myosin inhibitors were recently developed to address the underlying pathophysiology of hypertrophic cardiomyopathy and to improve symptoms and quality of life.Bryton J. Davis, Hailey Volk, Olives Nguyen, Daniel Kamna, Hongya Chen, Roberto Barriales‐Villa, Pablo Garcia‐Pavia, Iacopo Olivotto, Anjali T. Owens, Caroline J. Coats, Theodore P. Abraham, Scott D. Solomon, Martin S. Maron, Ahmad Masri +13 moredoaj +7 more sourcesCardiac myosin inhibitors: Efficacy, safety and future directions of aficamten in hypertrophic obstructive cardiomyopathy [PDF]
The Egyptian Heart JournalBackground Hypertrophic obstructive cardiomyopathy (HOCM) is a genetic disorder that affects the cardiac myocytes leading to asymmetric hypertrophy of the left ventricle and obstruction of the left ventricular outflow tract (LVOT) with possible risk of ...Ikponmwosa Jude Ogieuhi, Victor Oluwatomiwa Ajekiigbe, Boluwaduro Abasiekem Adeyemi, Bright Nwatamole, Komolafe Babajide Ayodeji, Oshomoh Mark-Anthony Ugiomoh, Temiloluwa Adebayo Odeniyi, Adewunmi Akingbola, Efosa Peace Iyawe, Olabode Olawale Oladejo, Motunrayo Oluwatoyosi Lawal, Nathnael Abera Woldehana, Ifeoluwa Sandra Bakare, Adejumo Temilade Patience, Grace Chinenye Okoro +14 moredoaj +4 more sourcesEfficacy of aficamten in obstructive hypertrophic cardiomyopathy: A systematic review and meta-analysis [PDF]
American Heart Journal PlusBackground: Obstructive hypertrophic cardiomyopathy (oHCM), a morbid hereditary condition, is characterized by asymmetrical intraventricular septum enlargement, obstructing blood flow from the left ventricle outflow tract (LVOT) and lowering cardiac ...Muhammad Nabeel Saddique, Hamza Irfan, Saad Ashraf, Maria Qadri, Hammad Javaid, Sana Iftikhar, Muhammad Zain ul Haq, Laveeza Fatima, Qasim Mehmood, Anurag Jha, Saad Masood, Muhammad Safiullah, Muhammad Imaz Bhatti, Sheena Shamoon, Javed Iqbal +14 moredoaj +4 more sourcesEffects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy [PDF]
Scientific Reports, 2023 Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiac disease in humans and cats and lacks efficacious pharmacologic interventions in the preclinical phase of disease.Ashley N. Sharpe, Maureen S. Oldach, Victor N. Rivas, Joanna L. Kaplan, Ashley L. Walker, Samantha L. Kovacs, Darren T. Hwee, Peadar Cremin, Bradley P. Morgan, Fady I. Malik, Samantha P. Harris, Joshua A. Stern +11 moredoaj +6 more sourcesAficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy [PDF]
New England Journal of MedicineOne of the major determinants of exercise intolerance and limiting symptoms among patients with obstructive hypertrophic cardiomyopathy (HCM) is an elevated intracardiac pressure resulting from left ventricular outflow tract obstruction. Aficamten is an oral selective cardiac myosin inhibitor that reduces left ventricular outflow tract gradients by ...Maron, Martin S, Masri, Ahmad, Nassif, Michael E, Barriales-Villa, Roberto, Arad, Michael, Cardim, Nuno, Choudhury, Lubna, Claggett, Brian, Coats, Caroline J, Düngen, Hans-Dirk, Garcia-Pavia, Pablo, Hagège, Albert A, Januzzi, James L, Lee, Matthew M Y, Lewis, Gregory D, Ma, Chang-Sheng, Michels, Michelle, Olivotto, Iacopo, Oreziak, Artur, Owens, Anjali T, Spertus, John A, Solomon, Scott D, Tfelt-Hansen, Jacob, van Sinttruije, Marion, Veselka, Josef, Watkins, Hugh, Jacoby, Daniel L, Heitner, Stephen B, Kupfer, Stuart, Malik, Fady I, Meng, Lisa, Wohltman, Amy, Abraham, Theodore P +32 morecore +8 more sourcesAficamten and Cardiopulmonary Exercise Test Performance [PDF]
JAMA CardiologyImportance: Impaired exercise capacity is a cardinal manifestation of obstructive hypertrophic cardiomyopathy (HCM). The Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic Obstructive HCM (SEQUOIA-HCM) is a pivotal study characterizing the treatment effect of aficamten, a next-in-class cardiac ...Lee, Matthew M. Y., Masri, Ahmad, Nassif, Michael E., Barriales-Villa, Roberto, Abraham, Theodore P., Claggett, Brian L., Coats, Caroline J., Gimeno, Juan Ramón, Kulac, Ian J., Landsteiner, Isabela, Ma, Changsheng, Maron, Martin S., Olivotto, Iacopo, Owens, Anjali T., Solomon, Scott D., Veselka, Josef, Jacoby, Daniel L., Heitner, Stephen B., Kupfer, Stuart, Malik, Fady I., Meng, Lisa, Wohltman, Amy, Lewis, Gregory D., null, null, Wang, Andrew, Sherrid, Mark V, Kelly, Jacob P, Marian, Ali J, Owens, Anjali Tiku, Wever-Pinzon, Omar, Owens, David, Wheeler, Matthew T, Nagueh, Sherif F, Rader, Florian, McGrew, Frank A, Wong, Timothy, O'Neill, Thomas, Bach, Richard G, Martinez, Matthew, Lakdawala, Neal K, Collado, Elias, Turer, Aslan, Desai Y, Milind, Hussain, Zainal, Tower-Rader, Albree F, Hannawi, Bashar, Geske, Jeffrey, Saberi, Sara, Phelan, Dermot, Kramer, Christopher, Sarswat, Nitasha, Ahmad, Ferhaan, Choudhury, Lubna, Markowitz, Jeremy S, Sen, Sounok, Bering, Patrick, Maron, Martin S, Jani, Sandeep, Brinkley, Douglas, Naidu, Srihari, Maurer, Mathew S, Moss, Noah, Bilen, Ozlem, Silva Enciso, Jorge, Fraser, Robert, Akinboboye, Olakunle, Asher, Craig, Emani, Sitaramesh, Sharma, Abhinav, Fermin, David, Lyle, Melissa, Raymer, David, Darlington, Andrew, Resnic, Frederic, Nielsen, Christopher D, Metra, Marco, Musumeci, Beatrice, Emdin, Michele, Targetti, Mattia, Canepa, Marco, Michels, Michelle, Knackstedt, Christian, Amin, Ahmad S., Barriales Villa, Roberto, Garcia Pavia, Pablo, Gimeno Blanes, Juan Ramon, Hidalgo Urbano, Rafael Jesus, Rincon Diaz, Luis Miguel, Ripoll Vera, Tomas Vicente V, Garcia Alvarez, Ana, Zemanek, David, Jensen, MortenK, Mogensen, Jens, Thune, Jens J, Bundgaard, Henning, Charron, Philippe, Trochu, Jean-Noel, Habib, Gilbert, Lhermusier, Thibault, Reant, Patricia, Hagege, Albert A, Logeart, Damien, Mitrovic, Veselin, Edelmann, Frank, Seidler, Tim, Meder, Benjamin, Schulze, Paul Christian, Stoerk, Stefan, Bekfani, Tarek, Rassaf, Tienush, Merkely, Bela, Arad, Michael, Halabi, Majdi, Zwas, Donna, Piltz, Xavier, Paz, Offir, Habib, Manhal, Dudek, Dariusz, Oreziak, Artur, Wojakowski, Wojciech, Toste Batista, Alexandra M, Mesquita Bastos, Jose Adelino, Elliott, Perry M, Mahmod, Masliza, Coats, Caroline, Cooper, Robert, Bradlow, William, Pantazis, Antonios, Tome Esteban, Maria Teresa, McGinnis, Shaina, Campain, Joseph, Cocca-Spofford, Diane, Giverts, Ilya, Griskowitz, Catherine, Newlands, Chloe, Moreno, Fabely Moreno +135 morecore +8 more sourcesConcomitant Aficamten and Disopyramide in Symptomatic Obstructive Hypertrophic Cardiomyopathy [PDF]
JACC: Heart FailureDisopyramide, used in obstructive hypertrophic cardiomyopathy (oHCM) for its negative inotropic properties mediated by its reduction in cytosolic calcium, has been recommended for decades as an option to relieve resistant obstruction. Aficamten is a selective cardiac myosin inhibitor that reduces hypercontractility directly by reducing myosin-actin ...Ahmad Masri, Martin S. Maron, Theodore P. Abraham, Michael E. Nassif, Roberto Barriales-Villa, Ozlem Bilen, Caroline J. Coats, Perry Elliott, Pablo Garcia-Pavia, Daniele Massera, Iacopo Olivotto, Artur Oreziak, Anjali Tiku Owens, Sara Saberi, Scott D. Solomon, Albree Tower-Rader, Stephen B. Heitner, Daniel L. Jacoby, Chiara Melloni, Jenny Wei, Mark V. Sherrid, Iacopo Olivotto, Michelle Michels, Roberto Barriales-Villa, Pablo Garcia-Pavia, Theodore P. Abraham, Lubna Choudhury, Christopher Kramer, Neal K. Lakdawala, Martin S. Maron, Ahmad Masri, Sherif F. Nagueh, Anjali Tiku Owens, Florian Rader, Sara Saberi, Mark V. Sherrid, John D. Symanski, Albree Tower-Rader, Aslan Turer, Andrew Wang, Timothy Wong, Yuhui Zhang, Haibo Yang, Chunli Shao, Zuyi Yuan, Qingchun Zeng, Xiaodong Li, Changsheng Ma, Yushi Wang, Yan Shu, Mulei Chen, Ling Tao, Xinli Li, Jingfeng Wang, Zaixin Yu, Xiang Cheng, Kui Hong, David Zemanek, Henning Bundgaard, Jens Thune, Morten Jensen, Jens Mogensen, Albert Hagège, Gilbert Habib, Philippe Charron, Thibault Lhermusier, Jean-Noël Trochu, Patricia Reant, Damien Logeart, Veselin Mitrovic, Tarek Bekfani, Frank Edelman, Tim Seidler, Benjamin Meder, Paul Christian Schulze, Stephan Stoerk, Tienush Rassaf, Bela Merkely, Donna Zfat-Zwas, Michael Arad, Majdi Halabi, Offir Paz, Xavier Piltz, Mattia Targetti, Marco Metra, Marco Canepa, Beatrice Musumeci, Michele Emdin, Michelle Michels, Ahmad Amin, Christian Knackstedt, Artur Oreziak, Wojciech Wojakowski, Dariusz Dudek, Alexandra Toste, José Mesquita Bastos, Roberto Barriales-Villa, Pablo Garcia Pavia, Juan Ramón Gimeno Blanes, Rafael Jesus Hidalgo Urbano, Ana Garcia Alvarez, Luis Miguel Rincón Diaz, Tomas Vicente Ripoll Vera, Perry Elliott, Caroline Coats, Robert Cooper, Masliza Mahmod, William Bradlow, Antonis Pantazis, Maria Teresa Tome Esteban, Ahmad Masri, Michael E. Nassif, Ali Marian, David Owens, Matthew Wheeler, Frank McGrew, Richard Bach, Omar Wever-Pinzon, Elias Collado, Aslan Turer, Bashar Hannawi, Jeffrey Geske, Anjali Tiku Owens, John D. Symanski, Christopher Kramer, Nitasha Sarswat, Ferhaan Ahmad, Theodore P. Abraham, Jeremy Markowitz, Neal Lakdawala, Lubna Choudhury, Sandeep Jani, Douglas M. Brinkley, Ozlem Bilen, Craig Asher, Sitaramesh Emani, Abhinav Sharma, David Fermin, Melissa Lyle, David Raymer, Andrew Darlington, Martin S. Maron, Christopher Nielsen, Andrew Wang, Sherif F. Nagueh, Matthew Martinez, Milind Desai, Albree Tower-Rader, Jacob Kelly, Florian Rader, Sounok Sen, Patrick Bering, Mathew Maurer, Sumeet Mitter, Mark V. Sherrid, Timothy Wong, Zainal Hussain, Sara Saberi, Srihari Naidu, Jorge Silva Enciso, David Zemanek, Henning Bundgaard, Morten Jensen, Jens Mogensen, Jens Thune, Erwan Donal, Gilbert Habib, Albert Hagege, Damien Logeart, Patricia Reant, Jean-Noël Trochu, Soeren Brandenburg, Frank Edelman, Benjamin Meder, Tienush Rassaf, Paul Christian Schulze, Stefan Stoerk, Bela Merkely, Michael Arad, Majdi Halabi, Xavier Piltz, Donna Zfat-Zwas, Michele Emdin, Beatrice Musumeci, Christian Knackstedt, Michelle Michels, Artur Oreziak, Wojciech Wojakowski, José Mesquita Bastos, Alexandra Toste, William Bradlow, Caroline Coats, Robert Cooper, Perry Elliott, Antonis Pantazis, Betty Raman, Maria Teresa Tome Esteban, Theodore P. Abraham, Kia Afshar, Said Alsidawi +199 morecore +9 more sources
