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Cardiac myosin inhibitors: Efficacy, safety and future directions of aficamten in hypertrophic obstructive cardiomyopathy [PDF]
The Egyptian Heart JournalBackground Hypertrophic obstructive cardiomyopathy (HOCM) is a genetic disorder that affects the cardiac myocytes leading to asymmetric hypertrophy of the left ventricle and obstruction of the left ventricular outflow tract (LVOT) with possible risk of ...Ikponmwosa Jude Ogieuhi, Victor Oluwatomiwa Ajekiigbe, Boluwaduro Abasiekem Adeyemi, Bright Nwatamole, Komolafe Babajide Ayodeji, Oshomoh Mark-Anthony Ugiomoh, Temiloluwa Adebayo Odeniyi, Adewunmi Akingbola, Efosa Peace Iyawe, Olabode Olawale Oladejo, Motunrayo Oluwatoyosi Lawal, Nathnael Abera Woldehana, Ifeoluwa Sandra Bakare, Adejumo Temilade Patience, Grace Chinenye Okoro +14 moredoaj +6 more sourcesGlobal Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM [PDF]
Circulation
BACKGROUND:
Nonobstructive hypertrophic cardiomyopathy (nHCM) is associated with significant morbidity with no approved treatment.Felix Jose Alvarez Ramires, Ethan J. Rowin, Rafik Tadros, Raquel Quesada, Stephen B. Heitner, David Murray, Joseph Selvanayagam, Pablo Garcia-Pavia, Albert Hagege, Luis Miguel Rincon Diaz, Marcos Hazday, Ali Hama Amin, Pedro Pimentel Filho, Scott D. Solomon, Maria Alejandra Restrepo Cordoba, Aijie Hou, Berglind Adalsteinsdottir, Christopher Bianco, Frank Edelmann, Carlos Eduardo Batista de Lima, Yuhui Zhang, Juan Ramón Gimeno Blanes, Maria Teresa Tome Esteban, Neal Lakdawala, Maria Angela Losi, Murillo Antunes, Liwen Li, Aris Anastasakis, Stuart Kupfer, Jeremy Markowitz, Sanjay Malhotra, Ozlem Bilen, Punag H. Divanji, Ahmad Masri, Xiaoyan Li, Bela Merkely, Jessica Wang, Anjali T. Owens, Robert Sepp, Sara Saberi, Natale Brunetti, Patrick Bering, Bashar Hannawi, Lubna Choudhury, Paul Christian Schulze, Thomas Morris Hey, Mark V. Sherrid, Gianfranco Sinagra, Dermot Phelan, Luiz Eduardo Ritt, Francois Roubille, Olga Azevedo, Kia Afshar, Massimo Piepoli, Benjamin Meder, Yang Zheng, Giancarlo Todiere, Gerasimos Filippatos, Donna Zwas, Shepard Weiner, Scott McKenzie, Atilio Costa Vitali, Steen H. Poulsen, Abid Assali, Bradley Lander, Yugang Dong, Daniel McDonald, Maurizio Volterrani, Oscar Salomone, Marshall Brinkley, Majdi Halabi, Zuyi Yuan, Theodore Abraham, Maria da Consolação Moreira, Damien Logeart, Rui Guerreiro, Josh Doll, Gregory D. Lewis, Edileide Barros Correia, Benjamin Tyrrell, Michael Arad, Marcus Vinicius Simões, Robert Cooper, Milind Desai, Christian Knackstedt, Martin S. Maron, Michelle Michels, Marco Metra, Gilbert Habib, Georgios Efthimiadis, José Francisco Kerr Saraiva, Tomas Vicente Ripoll Vera, Jose Manuel Garcia Pinilla, Sandeep Jani, William French, Perry Elliott, Jeffery Geske, Josef Stehlik, Patrycja Galazka, Jacob Kelly, Wei Ma, Nikhil Sikand, Ana Garcia Alvarez, Edileide de Barros Correia, Patricia Reant, Yongjun Li, Vimal Patel, Sriram Ravi, Caroline J. Coats, Jorge E. Silva Enciso, Jean-Etienne Ricci, Marta de Antonio Ferrer, Pankaj Arora, Soeren Brandenburg, Timothy Wong, Katie Halbmaier, Andrew Darlington, Ahmad Amin, Lia Crotti, Elias Collado, Maria Angeles Espinosa Castro, Albree Tower-Rader, Mariko Harper, Jesus E. Pino Moreno, Jens Jakob Thune, P. Christian Schulze, Jorge Silva Enciso, Florian Rader, Ronald Wharton, Maria Luisa Peña-Peña, Junbo Ge, John A. Spertus, Xavier Piltz, Fady I. Malik, Rafael Jesus Hidalgo Urbano, Michael Flanagan, Shelley Zieroth, Silvia Aguiar Rosa, Sumeet S. Mitter, Olivier Lairez, James Mudd, Ashwin Ravichandran, Bartosz Krakowiak, Jose Adelino Mesquita Bastos, Amy Wohltman, Mathew S. Maurer, Anna Maria Choy, Efstathia Prappa, Srihari Naidu, Iacopo Olivotto, Betty Raman, Mark Zenker, James MacNamara, Xiaoyan Zhao, Juan Pablo Costabel, Joel Salazar-Mendiguchía, Sherif Nagueh, Noah Moss, Carolyn Y. Ho, Wojciech Wojakowski, Wei Jin, Antonis Pantazis, Estevao Lanna Figueiredo, Andrew Caddell, Enrico Ammirati, Jessica Atkins, Ian Kulac, Estevão Figueiredo, Brian L. Claggett, Daniel L. Jacoby, Ankit Bhatia, Lola Xie, Charalambos Vlachopoulos, Michael E. Nassif, Shu Zhuo, Jesus Pino Moreno, Alexandra Toste Batista, Paola Roldan, Nicolas Piriou, Matthew W. Martinez, Roberto Barriales-Villa, Perry M. Elliott, Pedro Vellosa Schwartzmann, Markowitz, Jeremy, Dong, Yugang, Jin, Wei, Filippatos, Gerasimos, Vellosa Schwartzmann, Pedro, Zhao, Xiaoyan, Lairez, Olivier, Alvarez Ramires, Felix Jose, Sherrid, Mark V., Angela Losi, Maria, Krakowiak, Bartosz, Hidalgo Urbano, Rafael Jesus, Bilen, Ozlem, Maron, Martin S, Claggett, Brian L., Owens, Anjali T., Brinkley, Marshall, Reant, Patricia, Merkely, Bela, Wojakowski, Wojciech, French, William, Choudhury, Lubna, Lewis, Gregory D., Olivotto, Iacopo, Sinagra, Gianfranco, Pantazis, Antonis, Assali, Abid, da Consolação Moreira, Maria, Pino Moreno, Jesus E., Flanagan, Michael, Tower-Rader, Albree, Piepoli, Massimo, Batista de Lima, Carlos Eduardo, Li, Yongjun, McKenzie, Scott, Figueiredo, Estevão, Darlington, Andrew, Atkins, Jessica, Brunetti, Natale, Maria Choy, Anna, Sikand, Nikhil, Habib, Gilbert, Salazar-Mendiguchía, Joel, Zheng, Yang, Costa Vitali, Atilio, Ricci, Jean-Etienne, Garcia Pinilla, Jose Manuel, Antunes, Murillo, Silva Enciso, Jorge, Kulac, Ian, Tadros, Rafik, Garcia Alvarez, Ana, Naidu, Srihari, Peña-Peña, Maria Luisa, Hama Amin, Ali, Gimeno Blanes, Juan Ramón, Garcia-Pavia, Pablo, Sepp, Robert, Barriales-Villa, Roberto, Lakdawala, Neal, Figueiredo, Estevao Lanna, Spertus, John A., Nassif, Michael E., Adalsteinsdottir, Berglind, Murray, David, Metra, Marco, Knackstedt, Christian, Ravi, Sriram, McDonald, Daniel, Elliott, Perry M., Michels, Michelle, Jacoby, Daniel L., Todiere, Giancarlo, Meder, Benjamin, Desai, Milind, Hazday, Marcos, Anastasakis, Aris, Hou, Aijie, Vlachopoulos, Charalambos, Divanji, Punag H., de Barros Correia, Edileide, Elliott, Perry, Xie, Lola, Wang, Jessica, Azevedo, Olga, Harper, Mariko, Moss, Noah, Halabi, Majdi, Solomon, Scott D., Heitner, Stephen B., Mitter, Sumeet S., Hagege, Albert, Malhotra, Sanjay, Coats, Caroline J., Rincon Diaz, Luis Miguel, Roldan, Paola, Ripoll Vera, Tomas Vicente, Weiner, Shepard, H. Poulsen, Steen, Bering, Patrick, Rader, Florian, Zieroth, Shelley, Kupfer, Stuart, Arora, Pankaj, Raman, Betty, Halbmaier, Katie, Morris Hey, Thomas, Schulze, P. Christian, Amin, Ahmad, Kerr Saraiva, José Francisco, Jani, Sandeep, Martinez, Matthew W., Edelmann, Frank, Li, Liwen, Galazka, Patrycja, Afshar, Kia, Eduardo Ritt, Luiz, Zwas, Donna, Schulze, Paul Christian, Logeart, Damien, Doll, Josh, Kelly, Jacob, Ma, Wei, Nagueh, Sherif, Wohltman, Amy, Ammirati, Enrico, Bhatia, Ankit, Bianco, Christopher, Sherrid, Mark V, Espinosa Castro, Maria Angeles, Toste Batista, Alexandra, Ge, Junbo, Zhang, Yuhui, Selvanayagam, Joseph, Prappa, Efstathia, Brandenburg, Soeren, Phelan, Dermot, Costabel, Juan Pablo, Efthimiadis, Georgios, Jakob Thune, Jens, Collado, Elias, Tyrrell, Benjamin, Patel, Vimal, Malik, Fady I., Mudd, James, Stehlik, Josef, Ravichandran, Ashwin, Wong, Timothy, Rowin, Ethan J., Restrepo Cordoba, Maria Alejandra, Zenker, Mark, Vinicius Simões, Marcus, Saberi, Sara, Caddell, Andrew, Aguiar Rosa, Silvia, Piltz, Xavier, Guerreiro, Rui, Hannawi, Bashar, Pimentel Filho, Pedro, Ho, Carolyn Y., Barros Correia, Edileide, de Antonio Ferrer, Marta, Volterrani, Maurizio, Abraham, Theodore, Poulsen, Steen H., Tome Esteban, Maria Teresa, Piriou, Nicolas, Roubille, Francois, Crotti, Lia, Yuan, Zuyi, Lander, Bradley, Li, Xiaoyan, Geske, Jeffery, Pino Moreno, Jesus, Masri, Ahmad, Maurer, Mathew S., Cooper, Robert, Wharton, Ronald, Silva Enciso, Jorge E., Zhuo, Shu, Maron, Martin S., Arad, Michael, Mesquita Bastos, Jose Adelino, Quesada, Raquel, MacNamara, James, Salomone, Oscar +368 morecore +2 more sourcesPhysiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions of Aficamten in the Chinese Population [PDF]
Drug Design, Development and TherapyZiyang Wang, Xiaofei Wu, Ranran Jia, Hongyun WangClinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of China*These Wang Z, Wu X, Jia R, Wang Hdoaj +2 more sourcesSafety and Efficacy of Mavacamten and Aficamten in Patients With Hypertrophic Cardiomyopathy [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Cardiac myosin inhibitors were recently developed to address the underlying pathophysiology of hypertrophic cardiomyopathy and to improve symptoms and quality of life.Bryton J. Davis, Hailey Volk, Olives Nguyen, Daniel Kamna, Hongya Chen, Roberto Barriales‐Villa, Pablo Garcia‐Pavia, Iacopo Olivotto, Anjali T. Owens, Caroline J. Coats, Theodore P. Abraham, Scott D. Solomon, Martin S. Maron, Ahmad Masri +13 moredoaj +2 more sourcesMyosin Modulator Aficamten Inhibits Force by Altering Myosin’s Biochemical Activity Without Changing Thick Filament Structure [PDF]
JACC: Basic to Translational ScienceSummary: We investigated the effects of aficamten on cardiac muscle structure, biochemical activity, and contractile function. Aficamten does not structurally sequester myosin heads along the thick filament.Saffie Mohran, PhD, Kristina B. Kooiker, PhD, Ateeqa Naim, BS, Matvey Pilagov, BS, Anthony Asencio, BS, Kyrah L. Turner, BS, Weikang Ma, PhD, Galina Flint, MD., Siyao Jiang, BS, Jing Zhao, BS, Timothy S. McMillen, PhD, Christian Mandrycky, PhD, Max Mahoney-Schaefer, BS, Thomas C. Irving, PhD, Bertrand C.W. Tanner, PhD, Neil M. Kad, PhD, Michael Regnier, PhD, Farid Moussavi-Harami, MD +17 moredoaj +2 more sources
