Results 11 to 20 of about 108,706 (253)

Utility of combining PIVKA-II and AFP in the surveillance and monitoring of hepatocellular carcinoma in the Asia-Pacific region

Clinical and Molecular Hepatology, 2023
Even though the combined use of ultrasound (US) and alpha-fetoprotein (AFP) is recommended for the surveillance of hepatocellular carcinoma (HCC), the utilization of AFP has its challenges, including accuracy dependent on its cut-off levels, degree of ...
Do Young Kim, Bao Nguyen Toan, Chee‐Kiat Tan, I. Hasan, Lyana Setiawan, Ming‐Lung Yu, N. Izumi, Nguyen Nguyen Huyen, P. Chow, R. Mohamed, S. Chan, T. Tanwandee, Teng‐Yu Lee, Thị Hải, Tian Yang, Woonhyoung Lee, H. Chan   +16 more
semanticscholar   +1 more source

Multi-dimensional single-cell characterization revealed suppressive immune microenvironment in AFP-positive hepatocellular carcinoma

Cell Discovery, 2023
Alpha-fetoprotein (AFP)-secreting hepatocellular carcinoma (HCC), which accounts for ~75% of HCCs, is more aggressive with a worse prognosis than those without AFP production.
Hui-si He, Shuzhen Chen, Zhe-cai Fan, Ya-ping Dong, Y. Wang, Shiyao Li, Xiaojuan Sun, Yuting Song, Jinxian Yang, Qiqi Cao, Jie Jiang, Xian-Ming Wang, Wen Wen, Hongyang Wang   +13 more
semanticscholar   +1 more source

The Performance of AFP, AFP-3, DCP as Biomarkers for Detection of Hepatocellular Carcinoma (HCC). A Phase 3 Biomarker Study in the United States

Clinical Gastroenterology and Hepatology, 2022
Background: AFP, AFP L-3 and DCP in combination or in GALAD were tested for HCC surveillance in retrospective cohort and case-control studies. However, there is a paucity of prospective data and no phase 3 biomarker studies from North American ...
N. Tayob, F. Kanwal, A. Alsarraj, Ruben Hernaez, H. El‐Serag   +4 more
semanticscholar   +1 more source

The Role of Alpha-Fetoprotein (AFP) in Contemporary Oncology: The Path from a Diagnostic Biomarker to an Anticancer Drug

International Journal of Molecular Sciences, 2023
This article presents contemporary opinion on the role of alpha-fetoprotein in oncologic diagnostics and treatment. This role stretches far beyond the already known one—that of the biomarker of hepatocellular carcinoma.
Joanna Głowska-Ciemny, Marcin Szymanski, Agata Kuszerska, Z. Malewski, Constantin von Kaisenberg, R. Kocyłowski   +5 more
semanticscholar   +1 more source

PIVKA-II serves as a potential biomarker that complements AFP for the diagnosis of hepatocellular carcinoma

BMC Cancer, 2021
Background Hepatocellular carcinoma (HCC) is one of the most common malignant tumors of the digestive system and has high morbidity and mortality rates. It is essential to search new biomarkers to improve the accuracy of early HCC diagnosis.
Honglei Feng, Bole Li, Ze Li, Q. Wei, Liying Ren   +4 more
semanticscholar   +1 more source

AFP-L3 and DCP are Superior to AFP in Predicting Waitlist Dropout in Hepatocellular Carcinoma Patients: Results of a Prospective Study

Liver transplantation, 2023
In patients with HCC awaiting liver transplantation (LT), there is a need to identify biomarkers that are superior to AFP in predicting prognosis. AFP-L3 and des-gamma-carboxyprothrombin (DCP) play a role in HCC detection, but their ability to predict ...
N. Mehta, Prashant Kotwani, J. Norman, Amy M. Shui, P. J. Li, Varun Saxena, Wesley Chan, F. Yao   +7 more
semanticscholar   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Diagnostic Performance of AFP, AFP-L3, or PIVKA-II for Hepatitis C Virus-Associated Hepatocellular Carcinoma: A Multicenter Analysis

Journal of Clinical Medicine, 2022
Background and Aim: Alpha-fetoprotein (AFP), a lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), is a protein that is induced by vitamin K deficiency or antagonist-II (PIVKA-II) that has been clinically used as a serum biomarker for early ...
Si-yu Liu, Liyang Sun, Lan-Qing Yao, Hong Zhu, Yongkang Diao, Mingda Wang, H. Xing, W. Lau, Ming-Cheng Guan, T. Pawlik, F. Shen, Min Xu, Xiangmin Tong, Tian Yang   +13 more
semanticscholar   +1 more source

The threshold of alpha-fetoprotein (AFP) for the diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis

PLoS ONE, 2020
Objective Hepatocellular carcinoma (HCC) has become a pressing health problem facing the world today due to its high morbidity, high mortality, and late discovery.
Jiaxin Zhang, Guang Chen, Peng Zhang, Jiaying Zhang, Xiaoke Li, Danan Gan, Xu Cao, Mei Han, Hongbo Du, Y. Ye   +9 more
semanticscholar   +1 more source