Strategic delegation and risk‐taking in R&D: Partial delegation versus full delegation
Abstract We examine firm's risk‐taking decisions in R&D under two different delegation strategies between partial delegation (PD) and full delegation (FD): FD authorizes both quantity and R&D risk but PD only authorizes quantity. Cournot firms under the FD set higher profit weights at the expected value of cost realization, which can lessen competition,
Mingqing Xing, Sang‐Ho Lee
wiley +1 more source
Case Report: AFP-producing gastric hepatoid adenocarcinoma with multiple liver metastases - integrating quantitative imaging and diagnostic decision analysis. [PDF]
Zhong SY +7 more
europepmc +1 more source
ABSTRACT Background and Aims To evaluate the prognostic significance of pathological response in patients with initially unresectable hepatocellular carcinoma (uHCC) who underwent salvage resection after successful conversion with lenvatinib, anti‐PD‐1 antibodies, and locoregional therapy (LPLRT).
Qi‐Yu Chi +9 more
wiley +1 more source
Development and validation of a high-confidence diagnostic model integrating ctDNA methylation and serum biomarkers for early-stage hepatocellular carcinoma detection. [PDF]
Wu H +16 more
europepmc +1 more source
From Theory to Practice: Which Biomarkers Are Ready for Predicting Response in Advanced HCC?
ABSTRACT Systemic therapies for advanced hepatocellular carcinoma (HCC) have expanded considerably with the advent of tyrosine kinase inhibitors, immune checkpoint inhibitors and immunotherapy–anti‐angiogenic combinations. However, despite this therapeutic diversification, first‐line treatment selection remains largely empirical, as few biomarkers are ...
Marie Decraecker +3 more
wiley +1 more source
ABSTRACT Evidence supporting the safety and efficacy of immune checkpoint inhibitors (ICI) before liver transplantation (LTx) in hepatocellular carcinoma (HCC) is increasing, but risks of graft rejection and tumour recurrence remain major concerns. We evaluated post‐transplant outcomes across 10 European centres using data from the multinational LITCHI
Ulrike Bauer +22 more
wiley +1 more source
Long-Term Survival After Desperation Surgery for Primary Mediastinal Non-Seminomatous Germ Cell Tumor With Rising Alpha-Fetoprotein. [PDF]
Aigase T +9 more
europepmc +1 more source
Reversing Fatigue Damage in Carbon Fiber–Thermoplastic Composites Using Localized Plasma Heating
Schematic overview of the plasma‐assisted repair strategy for fatigue‐damaged short fiber carbon fiber/ABS composites. Pristine specimens are subjected to cyclic fatigue loading inducing damage. Localized plasma heating softens the thermoplastic matrix, enabling healing and restoring mechanical performance. Tensile testing is used to quantify recovery.
Hung Wang +5 more
wiley +1 more source
Discovering naturally occurring antifreeze peptides from microbiome by integrating protein language models and molecular dynamics simulation. [PDF]
Imam IA +5 more
europepmc +1 more source

