Results 181 to 190 of about 4,693,292 (348)

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

Advanced Science, EarlyView.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan, Ge Ge, LiQiu Liu, Sijun Hu, Miaomiao Tian, Yongzhan Nie, Zitong Zhao, Yongmei Song   +7 more
wiley   +1 more source

Scoping review of artificial intelligence via mobile technology and social media for health in Africa. [PDF]

Nat Commun
Baichoo S, Oladeji O, Villareal L, Diakabana H, Okekunle AP, Marivate V, Kaggwa F, Nsoesie EO.   +7 more
europepmc   +1 more source

Sexual relations and childbearing decisions of HIV-discordant couples: an exploratory study in South Africa and Tanzania [PDF]

, 2011
Laetitia C. Rispel, Carol Metcalf, Kevin Moody, Allanise Cloete, Georgina Caswell   +4 more
openalex   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Health data science revolution in Africa: potential for addressing the myriad health challenges. [PDF]

Nat Commun
Amegah AK, Kyobutungi C, Chimusa ER.
europepmc   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

The 2024-2025 upsurge of mpox in Africa: another opportunity to accelerate global solidarity for a neglected disease. [PDF]

BMJ Glob Health
Onyeaghala C, Iroezindu M.
europepmc   +1 more source

Edible Insects in Africa in Terms of Food, Wildlife Resource, and Pest Management Legislation

, 2020
Nils Th. Grabowski, S. Tchibozo, Amir Abdulmawjood, Fatma Acheuk, Meriem Msaad Guerfali, Waheed A. A. Sayed, Madeleine Plötz   +6 more
openalex   +1 more source

Analyses of African common bean (Phaseolus vulgaris L.) germplasm using a SNP fingerprinting platform: diversity, quality control and molecular breeding [PDF]

, 2019
Bodo Raatz, Clare Mukankusi, Juan David Lobaton, Alan Male, Virginia Chisale, Berhanu Amsalu, Deidré Fourie, Floride Mukamuhirwa, Kennedy Muimui, Bruce Mutari, Susan Nchimbi‐Msolla, Stanley T. Nkalubo, Kidane Tumsa, Rowland Chirwa, Mywish K. Maredia, Chunlin He   +15 more
openalex   +1 more source