Results 101 to 110 of about 13,631,366 (252)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Work Hours Constraints: Impacts and Policy Implications [PDF]

open access: yes
If individuals reveal their preference as consumers, then they are taken seriously. What happens if individuals, as employees, reveal their preferences in working hours?
Constant, Amelie F., Otterbach, Steffen
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Does downsizing take a toll on retained staff? An analysis of increased working hours during recessions using Japanese micro data [PDF]

open access: yes
Using official household micro data from the Labour Force Survey, this paper examines the increase in the working hours of regular male employees in Japan under recession from the late 1990s to the early 2000s.
Ohta, Souichi   +2 more
core  

Dental re-implantation 72 hours after avulsion

open access: yesRevista Cubana de Estomatología, 2014
The dental re-implantation is one of the procedures demanding most rigor and precision in terms of the conditions required to achieve the expected success.
Alain Manuel Chaple Gil   +1 more
doaj  

The impact of the COVID-19 pandemic on antibiotic prescription rates in out-of-hours primary care – a register-based study in Denmark

open access: yesScandinavian Journal of Primary Health Care
Background Antibiotic prescription rates can be affected by pandemic measures such as lockdowns, social distancing, and remote consultations in general practice.
Emil Krogh   +5 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Long work hours and the wellbeing of fathers and their families [PDF]

open access: yes
The average hours worked by full-time employees in Australia have increased since the late 1970s. This, combined with increases in female labour force participation, has led to concerns about the impact of long work hours on family life.
Lixia Qu   +3 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Working Hours in Supply Chain Chinese and Thai Factories: Evidence From the Fair Labor Association’s ‘Soccer Project’ [PDF]

open access: yes
This paper examines the determinants of working excessive hours, defined as working in excess of 60 hours per week or for more than six consecutive days, in Chinese and Thai supply-chain factories.
Ines Kaempfer   +2 more
core  

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