Results 51 to 60 of about 15,684,264 (247)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Quality of after-hours primary care in the Netherlands: a narrative review [PDF]
, 2011 Contains fulltext : 98271.pdf (Publisher’s version ) (Closed access)Many Western countries are seeking an organizational model for after-hours primary care that is safe, efficient, and satisfactory for patients and health care ...
Huibers, L. +9 more
core +1 more source
BMC Family Practice, 2021 Background High demands create pressure on acute care services, such as emergency medical services (EMS), emergency departments (ED) and out-of-hours primary care (OOH-PC) services.
Ellen Keizer +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A plan for strengthening pediatric emergency care: establishment of pediatric certified emergency center [PDF]
Pediatric Emergency Medicine Journal, 2017 Pediatric patients (younger than 19 years) account for approximately 25% of all emergency patients. Pediatric patients have large proportions of toddlers (aged 1-5 years), low severity, illness (rather than injury), and after-hours visits.
Sangmo Je, Jeong-Seok Hong, Ji Sook Lee
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Palliative Medicine in PracticeINTRODUCTION: In Poland, legal requirements for the provision of palliative care and patients’ social conditions have changed since the hospice movement began in the 1980s. There has been a lack of comparative assessments regarding home-based hospice and
Katarzyna Grądalska, Tomasz Grądalski
doaj +1 more source
BMC Public Health, 2019 Background The acute out-of-hours healthcare services are challenged by increasing demand in many countries. We aimed to examine factors influencing the intended help-seeking in out-of-hours care for acute health problems during evenings, nights, and ...
Ellen Keizer +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Our study found after-hours GPs actually do reduce visits to emergency rooms [PDF]
, 2017 A taskforce reviewing more than 5,700 items covered by the Medicare Benefits Schedule (MBS) released a preliminary report this week on urgent after-hours GP services funded through the MBS.
Ifediora, Christian
core