Results 101 to 110 of about 13,631,366 (252)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Work Hours Constraints: Impacts and Policy Implications [PDF]

If individuals reveal their preference as consumers, then they are taken seriously. What happens if individuals, as employees, reveal their preferences in working hours?
Constant, Amelie F., Otterbach, Steffen
core  

The Effect of After-Hours Mobile Connectivity on Work-Family Conflict and Psychological Detachment: A Meta-Analysis Study

Educational Process: International Journal
Background/purpose. Mobile technologies have brought about significant changes in human life over the past quarter-century. The greatest advantages offered by these technologies, which have had a profound impact across a wide range of areas from work ...
Ecehan Kazancı Yabanova
doaj   +1 more source

Does parents’ socioeconomic position affect the accuracy of the level of care assigned to their children in out-of-hours primary care? A combined observational and register-based exploratory study in Denmark

BMC Primary Care
Background Adults with low socioeconomic position (SEP) are often provided poorer healthcare than adults with high SEP. Parents’ SEP affects their children’s health, but the mechanisms of this association remain to be explained.
Lotte Bjerre Lassen, Dennis Schou Graversen, Morten Bondo Christensen, Fredrik Folke, Linda Huibers, Anette Fischer Pedersen   +5 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Does downsizing take a toll on retained staff? An analysis of increased working hours during recessions using Japanese micro data [PDF]

Using official household micro data from the Labour Force Survey, this paper examines the increase in the working hours of regular male employees in Japan under recession from the late 1990s to the early 2000s.
Ohta, Souichi, Kuroda, Sachiko, Genda, Yuji   +2 more
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Long work hours and the wellbeing of fathers and their families [PDF]

The average hours worked by full-time employees in Australia have increased since the late 1970s. This, combined with increases in female labour force participation, has led to concerns about the impact of long work hours on family life.
Lixia Qu, David Stanton, Ruth Weston, Matthew Gray   +3 more
core  

The impact of the COVID-19 pandemic on antibiotic prescription rates in out-of-hours primary care – a register-based study in Denmark

Scandinavian Journal of Primary Health Care
Background Antibiotic prescription rates can be affected by pandemic measures such as lockdowns, social distancing, and remote consultations in general practice.
Emil Krogh, Katrine Bjørnshave Bomholt, Mette Amalie Nebsbjerg, Claus Høstrup Vestergaard, Morten Bondo Christensen, Linda Huibers   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source