Results 21 to 30 of about 30,636 (221)

Afterload-related reference values for myocardial work indices

Cardiovascular Ultrasound, 2021
Background The novel noninvasive pressure-strain loop (PSL) is a reliable tool that reflects myocardial work (MW). Systolic blood pressure (SBP) is the only independent factor for MW indices.
Qiancheng Li, Hui Wang, Haiyan Feng, Tingfan Wu, Ying Yang, Dongmei Gao, Lina Sun   +6 more
doaj   +1 more source

Different activation of MAPKs and Akt/GSK3β after preload vs. afterload elevation

ESC Heart Failure, 2022
Aims Pressure overload (PO) and volume overload (VO) lead to concentric or eccentric hypertrophy. Previously, we could show that activation of signalling cascades differ in in vivo mouse models. Activation of these signal cascades could either be induced
Nico Hartmann, Lena Preuß, Belal A. Mohamed, Moritz Schnelle, Andre Renner, Gerd Hasenfuß, Karl Toischer   +6 more
doaj   +1 more source

Weaning from venous-arterial extracorporeal membrane oxygenation: The hemodynamic and clinical aspects of flow challenge test

Frontiers in Medicine, 2022
The cardiac function reserve is crucial for the successful weaning of V-A ECMO. During the V-A ECMO weaning phase, the gradual reduction in pump flow converts the blood flow originally driven by the pump to native cardiac output and also transforms ...
Jing-chao Luo, Yi-jie Zhang, Jun-yi Hou, Ming-hao Luo, Ming-hao Luo, Kai Liu, Guo-wei Tu, Zhe Luo, Zhe Luo, Zhe Luo   +9 more
doaj   +1 more source

Reversible LV Dysfunction After TAVR

Indian Journal of Clinical Cardiology, 2020
Aortic stenosis (AS) is characterized by gradual thickening, fibrosis, and calcification leading to reduced opening of aortic valve leaflets. Aortic valve narrowing increases the afterload on left ventricle (LV), which consequently leads to hypertrophy ...
Sreenivas Kumar Arramraju, Rama Krishna Janapati, Sudhakar Reddy Pathakota, Sanjeeva Kumar E, Gokul Reddy Mandala   +4 more
doaj   +1 more source

The Impact of Left Ventricular Performance and Afterload on the Evaluation of Aortic Valve Stenosis: A 1D Mathematical Modeling Approach

Bioengineering, 2023
The transaortic valvular pressure gradient (TPG) plays a central role in decision-making for patients suffering from severe aortic stenosis. However, the flow-dependence nature of the TPG makes the diagnosis of aortic stenosis challenging since the ...
Cemre Çelikbudak Orhon, Nikolaos Stergiopulos, Stéphane Noble, Georgios Giannakopoulos, Hajo Müller, Dionysios Adamopoulos   +5 more
doaj   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Validation of femoral pressure-derived assessment of effective arterial elastance in porcine ischemic cardiogenic shock

Frontiers in Cardiovascular Medicine
BackgroundDuring ischemic cardiogenic shock (CS), increased afterload overburdens the damaged myocardium and may worsen outcomes. The measure, effective arterial elastance (Ea), integrates systemic vascular resistance, arterial compliance, and heart rate,
Oskar Kjærgaard Hørsdal, Oskar Kjærgaard Hørsdal, Nigopan Gopalasingam, Nigopan Gopalasingam, Kristoffer Berg-Hansen, Kristoffer Berg-Hansen, Roni Nielsen, Roni Nielsen   +7 more
doaj   +1 more source

Increased Afterload Augments Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model

JACC: Basic to Translational Science, 2018
Summary: Sunitinib, a multitargeted oral tyrosine kinase inhibitor, used widely to treat solid tumors, results in hypertension in up to 47% and left ventricular dysfunction in up to 19% of treated individuals.
Rachel Truitt, PhD, Anbin Mu, Elise A. Corbin, PhD, Alexia Vite, PhD, Jeffrey Brandimarto, PhD, Bonnie Ky, MD, MSCE, Kenneth B. Margulies, MD   +6 more
doaj   +1 more source

P.68 WaveGraft–A Novel Endovascular Device Concept for Restoring the Natural Arterial Cushioning Effect

Artery Research, 2020
Background and Objectives: The cushioning effect of large, healthy arteries reduces pulsatile afterload to the heart, reduces pulsatility in the microvasculature of target organs, and promotes coronary/cerebral perfusion [1].
Florian Stefanov, Dave Veerasingam, Sarah Sayed, Patrick Delassus, Jonathan Bouchier-Hayes, Liam Morris   +5 more
doaj   +1 more source

Association of COPD with adverse outcomes in heart failure patients with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 799-808, April 2025.
Abstract We performed a systematic review and meta‐analysis to detect the impact of chronic obstructive pulmonary disease (COPD) on the prognosis of heart failure patients with preserved ejection fraction (HFpEF). We systematically screened eligible literature from three electronic databases, PubMed, EMBASE and Cochrane Library, up to April 2023.
Shuo Xu, Zhenbang Gu, Wengen Zhu, Shenghui Feng   +3 more
wiley   +1 more source