Results 1 to 10 of about 20 (14)

Control of Palmer Amaranth in Agronomic Crops [PDF]

EDIS, 2011
SS-AGR-338, a 5-page fact sheet by J. Ferrell, B. Brecke, and C. Smith, provides producers with examples of diverse program approaches for managing Palmer amaranth in corn, cotton, peanut, and soybean. Published by the UF Department of Agronomy, December
Jason Ferrell, Barry Brecke, Clyde Smith
doaj   +8 more sources

Innovative Treatments for Rare Anemias. [PDF]

Hemasphere, 2021
Rare anemias (RA) are mostly hereditary disorders with low prevalence and a broad spectrum of clinical severity, affecting different stages of erythropoiesis or red blood cell components. RA often remains underdiagnosed or misdiagnosed, and treatment options have been limited to supportive care for many years.
Cappellini MD, Marcon A, Fattizzo B, Motta I.   +3 more
europepmc   +2 more sources

AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes

Haematologica, 2020
Pyruvate kinase (PK) deficiency is a rare hereditary disorder affecting red cell (RBC) glycolysis, causing changes in metabolism including a deficiency in ATP.
Minke A.E. Rab, Brigitte A. van Oirschot, Penelope A. Kosinski, Jeffrey Hixon, Kendall Johnson, Victor Chubukov, Lenny Dang, Gerard Pasterkamp, Stephanie van Straaten, Wouter W. van Solinge, Eduard J. van Beers, Charles Kung, Richard van Wijk   +12 more
doaj   +1 more source

Influence of the pyruvate kinase activator mitapivat (AG-348) on RBC ATP content and export and RBC adhesivity in blood from healthy subjects and sickle cell disease patients

Frontiers in Hematology
BackgroundSickle cell disease (SCD) represents a significant global health burden and is characterized by hemolytic anemia, vaso-occlusive crises, end-organ damage, and early mortality.
Apoorva Jagadish, Youwei Chen, Hongmei Zhu, Hongmei Zhu, Weijia Mai, Shein-Chung Chow, Zhong Li, Grace M. Lee, Marilyn J. Telen, Tim J. McMahon, Tim J. McMahon   +10 more
doaj   +1 more source

Targeting the red cell enzyme pyruvate kinase with a small allosteric molecule AG-348 may correct underlying pathology of a glycolytic enzymopathy

Haematologica, 2021
Abdu I. Alayash
doaj   +1 more source

The International Hemoglobinopathy Research Network (INHERENT): An international initiative to study the role of genetic modifiers in hemoglobinopathies. [PDF]

Am J Hematol, 2021
Kountouris P, Stephanou C, Archer N, Bonifazi F, Giannuzzi V, Kuo KHM, Maggio A, Makani J, Mañú-Pereira MDM, Michailidou K, Nkya S, Nnodu OE, Trompeter S, Tshilolo L, Wonkam A, Zilfalil BA, Inusa BPD, Kleanthous M, on behalf of the International Hemoglobinopathy Research Network (INHERENT).   +18 more
europepmc   +1 more source

Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health. [PDF]

Cell Metab, 2020
Abulizi A, Cardone RL, Stark R, Lewandowski SL, Zhao X, Hillion J, Ma L, Sehgal R, Alves TC, Thomas C, Kung C, Wang B, Siebel S, Andrews ZB, Mason GF, Rinehart J, Merrins MJ, Kibbey RG.   +17 more
europepmc   +1 more source

Contribution of personalized Cyclin D1 genotype to triple negative breast cancer risk. [PDF]

Biomedicine (Taipei), 2014
Liu LC, Su CH, Wang HC, Chang WS, Tsai CW, Maa MC, Tsai CH, Tsai FJ, Bau DT.   +8 more
europepmc   +1 more source

Relationships between cell cycle pathway gene polymorphisms and risk of hepatocellular carcinoma. [PDF]

World J Gastroenterol, 2016
Nan YL, Hu YL, Liu ZK, Duan FF, Xu Y, Li S, Li T, Chen DF, Zeng XY.   +8 more
europepmc   +1 more source

Disproportionate Decline in Trabecular Bone Score Compared to Bone Mineral Density in Southeast Asian Patients with Thalassemia: A Matched Control Study. [PDF]

Calcif Tissue Int
Pongchaiyakul C, Teawtrakul N, Theerakulpisut D, Sribenjalak D, Charoenngam N.   +4 more
europepmc   +1 more source