Results 121 to 130 of about 10,916 (204)

Unraveling the Plasma Extracellular Vesicles Proteome: Predictors of Resistance in Immunotherapy of Advanced Melanoma

International Journal of Cancer, EarlyView.
ABSTRACT Despite substantial clinical benefit from immune checkpoint inhibitors (ICI), advanced melanoma remains challenging due to frequent treatment resistance. Resistance may be intrinsic (primary) or emerge over time (secondary). Biomarkers predicting distinct resistance phenotypes before therapy are lacking.
Julian Kött, Glenn Geidel, Carmen M. T. Roeper, Lucija Ačkar, Bente Siebels, Hannah Voß, Hartmut Schlüter, Michaela Schweizer, Kilian Müller, Alessandra Rünger, Tim Zell, Benjamin Deitert, Ali Zeinal‐Abedini, Isabel Heidrich, Stefan W. Schneider, Klaus Pantel, Daniel J. Smit, Christoffer Gebhardt   +17 more
wiley   +1 more source

Introduction to Genetics: AGC 312

, 2011
Introduction to Genetics: AGC 312, supplementary examination July ...
Chiduza, C, Mutengwa, C S
core  

HPV Genotype Distribution in Cervical Cancer and High‐Grade Lesions in Norway, and Early Vaccine Impact

International Journal of Cancer, EarlyView.
ABSTRACT All cases of invasive cervical cancer (ICC) and subsets of high‐grade cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3) and adenocarcinoma in situ (AIS) in Norway are tested for 37 human papillomavirus (HPV) genotypes, within a mandatory national surveillance system.
Terese Bekkevold, Ida Laake, Berit Feiring, Kristiane Søreng, Gro Kummeneje Presthus, Glenny Cecilie Alfsen, Irene Kraus Christiansen, Mona Hansen, Hanne Kristiansen, Eirik Olsen, Torstein Gjølgali Frengen, Emily A. Burger, Christine Genieve Monceyron Jonassen, Lill Trogstad   +13 more
wiley   +1 more source

Plant Pest Control: AGC 313

, 2011
Plant Pest Control: AGC 313, supplementary examination January ...
Maphaha, M, Maphuha, M, Mutengwa, C
core  

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Foreword to: Indiana University’s Response to the Addictions Crisis: A Grand Challenge Initiative

Inquiry: The Journal of Health Care Organization, Provision, and Financing
Use of heroin, prescription painkillers, methamphetamines, and fentanyl led to a national health crisis in 2017, resulting in 1852 overdose deaths in Indiana. Governor Eric J. Holcomb made tackling substance use in the state one of his highest priorities,
Robin Newhouse PhD, RN, FAAN
doaj   +1 more source

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Operation of rapid start units in an AGC area [PDF]

, 2012
Artículos en revistasRapid Start units can be used in an AGC area as units that can participate in AGC regulation but that remain offline until they are needed.
Egido Cortés, Ignacio, Saboya Bautista, Inmaculada, Rouco Rodríguez, Luis, Fernández Bernal, Fidel   +3 more
core  

Innovative Method for Evaluating the Optical Properties of Liquid–Liquid Phase Separations Using Laser Scanning Microscopic Spectroscopy

Microscopy Research and Technique, EarlyView.
The LLPS phenomenon in the optoDroplet method can be discerned through the use of fluorescent molecular spectroscopy, which enabled the distinction between droplet formation and gelation. ABSTRACT Liquid–liquid phase separation (LLPS) plays a central role in intracellular compartmentalization and gene regulation.
Johbu Itoh, Natsuko Fujii, Saori Kohara, Masatoshi Ito, Naoto Suzuki, Eiichiro Nagata   +5 more
wiley   +1 more source

Leveraging Isomerization of Azo Dyes and Imines for the Facile Synthesis of Oxadiazepines and Related Heterocycles

Journal of Heterocyclic Chemistry, EarlyView.
A robust method for synthesizing substituted oxadiazepines and related heterocycles via intramolecular SNAr is detailed. Under mild conditions, this methodology has been leveraged to afford products of varying electronic and aryl nature in up to 99% yields.
Matthew W. Reeves, Christian A. Guzman, Herbi Yuliantoro, Peng Li, Elizabeth R. Young   +4 more
wiley   +1 more source