Results 191 to 200 of about 235,628 (343)

Harnessing oligonucleotide architecture for potent multivalent inhibition of human carbonic anhydrases. [PDF]

RSC Med Chem
Abbass EM, Ladu F, Mansot J, Noël M, Nocentini A, Sechi M, Supuran CT, Smietana M, Winum JY.   +8 more
europepmc   +1 more source

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

Brain Pathology, EarlyView.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma, Robert Blair, Yao‐Zhong Liu, Xiaolei Wang, Eunice Vincent, Christopher Yu, Lara A. Doyle‐Meyers, Cissy Zhang, Ahmad Saied, Anne Le, Ronald S. Veazey, Qigui Yu, Huanbin Xu   +12 more
wiley   +1 more source

Predictors of acute gangrenous cholecystitis and its complications: a retrospective cohort study. [PDF]

BMC Surg
El Asmar N, Rizk C, Malak D, Ibrahim MA, Tawil A, Elbejjani M, Barada K.   +6 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Locally synthesized glycyl aminoacyl-tRNA synthetase is important for local translation in neurons. [PDF]

Life Sci Alliance
de Leon TB, Golani-Armon A, Cohen B, Arava YS.   +3 more
europepmc   +1 more source

In rats, neurodevelopmental disorders induced by maternal hypoxia are associated with attenuated excitatory neurotransmission in the cingulate cortex

British Journal of Pharmacology, EarlyView.
Background and Purpose Maternal hypoxia is a recognised risk factor for neurodevelopmental disorders in offspring. Although rodent models of hypoxia have been reported, the detailed pathogenesis of maternal hypoxia‐induced neurodevelopmental disorders remains unclear.
Kentaro Tokudome, Masaaki Ueki, Takujiro Homma, Shinji Matsunaga, Saki Shimizu, Yukihiro Ohno, Shuhei Tomita   +6 more
wiley   +1 more source

AGC-2 Disassembly Report [PDF]

, 2014
openaire   +1 more source

Efficacy and safety of nivolumab plus chemotherapy in patients with advanced gastric cancer with massive ascites. [PDF]

World J Gastrointest Oncol
Matsumoto T, Sugimoto S, Omori R, Makiyama C, Nakasya A, Nagai H, Yasui H, Higashi R, Sasamoto A, Satake H.   +9 more
europepmc   +1 more source

ITGA5 as a Dual Regulator of Epithelial‐Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction

Cell Proliferation, EarlyView.
Proteomics and functional validation reveal ITGA5 as a dual promoter of epithelial‐mesenchymal transition and anoikis resistance in human bronchial epithelium: targeting ITGA5 represents a novel therapeutic strategy for asthma airway remodelling. ABSTRACT Airway remodelling is a major contributor to persistent airflow limitation and irreversible lung ...
Ting Wang, Ling Rao, Xiaofang Li, Miaofen Zhang, Huiting Huang, Zhiyan Luo, Gang Liao, Yong Jiang, Shaofeng Zhan, Qiong Liu, Xiufang Huang   +10 more
wiley   +1 more source

A novel Hankel norm approximation-based AGC for a hydro-dominated power system. [PDF]

Sci Rep
Naqvi S, Ibraheem, Sharma G, Kumar R, Sharma S.   +4 more
europepmc   +1 more source