Results 121 to 130 of about 1,986,358 (294)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Clinical Applicability of Various Digital Softwares Used in Forensic Odontology for Age Estimation Using Teeth on Cone-beam Computed Tomography Imaging: A Systematic Review and Meta-Analysis

Journal of Medical Physics
Background and Aim: Forensic odontology plays a crucial role in age estimation and personal identification, especially in cases where only dental remains are available. In a similar context, various newer innovations in digital software are a key tool to
Gandikota Kartheek, G. Santhosh Reddy, Kolasani Balaram, Sameena Parveen, P. Veeralakshmi, Sally Hassan Abobaker, J. Suresh Babu, C. Swarnalatha, Abhishek Singh Nayyar   +8 more
doaj   +1 more source

Forensic Age Estimation.

Deutsches Arzteblatt international, 2017
Forensic age estimation is requested by courts and other government authorities so that immigrants whose real age is unknown should not suffer unfair disadvantages because of their supposed age, and so that all legal procedures to which an individual's age is relevant can be properly followed.
Andreas, Schmeling, Reinhard, Dettmeyer, Ernst, Rudolf, Volker, Vieth, Gunther, Geserick   +4 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Determining the Chronological Age of Children Living in the Mediterranean Region Using Different Radiological Methods and Age Estimation Methods

Journal of Behçet Uz Children's Hospital
Objective: The aim of this study was to evaluate the suitability of three age estimation methods, using different radiological techniques, for estimating the chronological age (CA) of children living in the Mediterranean region, and whether these methods
Berna Kuter, Ceren Sağlam, Fahinur Ertuğrul, Neşe Güler   +3 more
doaj   +1 more source

Some notes on how to catch a red herring Ageing, time-to-death & care costs for older people in Sweden [PDF]

In this paper we test the 'red herring' hypothesis for expenditures on long-term care. The main contribution of this paper is that we assess the 'red herring' hypothesis using an aggregated measure that allows us to control for entering the final period ...
Karlsson, Martin, Klohn, Florian
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Craniometric Method for Age Estimation by the Degree of Lambdoid Suture Obliteration

Инновационная медицина Кубани
Background: In anthropology age of skeletal remains can be estimated without specific equipment by the degree of serrate suture obliteration; however, standard methods of obliteration measurement cannot be used to calculate age of a skull with a ...
S. E. Baybakov, N. S. Bakhareva, E. K. Gordeeva, K. O. Lifenko, D. A. Vasilchenko, E. V. Yakovleva, N. A. Fedko, S. I. Solozhenko   +7 more
doaj   +1 more source