Results 111 to 120 of about 2,722,532 (270)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Development of Phonetic inventory in 2-to-6 year-old Farsi speaking children

مجله پژوهش در علوم توانبخشی, 2010
Introduction: Children say the first words in the end of their first year of life. As children grow, the number of words and phonemes in their phonetic inventory increases.The first appearing consonants in the children's phonetic inventory are nasal ...
Zeinab Damerchi, Nahid Jalilehvand, Behrooz Bakhtiari, Mohammad Reza Keyhani   +3 more
doaj   +1 more source

Computer-assisted transcription and analysis of speech [PDF]

, 2001
The two papers included in this volume have developed from work with the CHILDES tools and the Media Editor in the two research projects, "Second language acquisition of German by Russian learners", sponsored by the Max Planck Institute for ...
Bast, Conny, Lehmann, Katrin, Stephany, Ursula   +2 more
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Should R&D Champions be Protected from Foreign Takeovers? [PDF]

We analyze how the entry mode of Foreign Direct Investments (FDI) affects affiliate R&D activities. Using unique affiliate level data for Swedish multinational firms, we first present empirical evidence that acquired affiliates have a higher level of R&D
Bertrand, Olivier, Nilsson Hakkala, Katariina, Norbäck, Pehr-Johan, Persson, Lars   +3 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Age-dependent acquisition of pathogenicity by SARS-CoV-2 Omicron BA.5. [PDF]

Sci Adv, 2023
Imbiakha B, Ezzatpour S, Buchholz DW, Sahler J, Ye C, Olarte-Castillo XA, Zou A, Kwas C, O'Hare K, Choi A, Adeleke RA, Khomandiak S, Goodman L, Jager MC, Whittaker GR, Martinez-Sobrido L, August A, Aguilar HC.   +17 more
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

What's on the inside counts: A grounded account of concept acquisition and development

Frontiers in Psychology, 2016
Understanding the factors which affect the age of acquisition (AoA) of words and concepts is fundamental to understanding cognitive development more broadly.
Serge eThill, Katherine eTwomey
doaj   +1 more source

How Age of Acquisition Affects Compound Word Recognition

Scientific Studies of Reading
Purpose: Adults recognise words that are acquired during childhood more quickly than words acquired during adulthood. This is known as the Age of Acquisition (AoA) effect. The AoA effect, according to the integrated account, manifests in tasks necessitating greater semantic processing and in tasks with arbitrary input-output mapping.
Mahmoud Medhat Elsherif, Jon Catling
openaire   +1 more source