Results 81 to 90 of about 2,722,532 (270)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Dissociating word frequency and age of acquisition: The Klein effect revived (and reversed). [PDF]

, 2006
The Klein effect (G. S. Klein, 1964) refers to the finding that high-frequency words produce greater interference in a color-naming task than low-frequency words.
Barry, Christopher, Dewhurst, Stephen A.
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Implicit and Explicit Knowledge of a Multiple Interface Phenomenon: Differential Task Effects in Heritage Speakers and L2 Speakers of Spanish in The Netherlands

Languages, 2018
This paper compares heritage speakers and second language (L2) speakers of Spanish with Dutch as their dominant language, in order to explore the role of age of onset and manner of acquisition in the nature of the knowledge (implicit vs. explicit) of the
Brechje van Osch, Aafke Hulk, Suzanne Aalberse, Petra Sleeman   +3 more
doaj   +1 more source

Contact, the feature pool and the speech community : The emergence of Multicultural London English. [PDF]

, 2011
In Northern Europe’s major cities, new varieties of the host languages are emerging in the multilingual inner cities. While some analyse these ‘multiethnolects’ as youth styles, we take a variationist approach to an emerging ‘Multicultural London English’
Androutsopoulos, Bickerton, Britain, Britain, Britain, Brown, Buchstaller, Castells, Chambers, Chambers, Cheshire, Cheshire, Clyne, Eckert, Gabrielatos, Hickey, Horvath, Inwood, Kerswill, Kerswill, Kerswill, Kerswill, Kerswill, Kotsinas, Krashen, Labov, Labov, Labov, Labov, Labov, Labov, Labov, Lapidus, Lass, Le Page, Lobanov, Macaulay, Mesthrie, Meyerhoff, Milroy, Milroy, Mufwene, Newton, Quist, Rampton, Roberts, Schilling-Estes, Schumann, Sebba, Sebba, Siegel, Smith, Svendsen, Tagliamonte, Thomason, Torgersen, Torgersen, Trudgill, Watermeyer, Wells, Wiese, Wiese, Winford   +62 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Predictors of naming latencies in Lebanese Arabic using a set of 274 images

Psychology of Language and Communication
Picture-naming tasks are a widely used experimental paradigm in investigating aspects of lexical retrieval and in clinical evaluations. Psycholinguistic properties pertaining to pictorial stimuli differ across pictures and may impact the speed and ...
Kanj Rama, Nasser Maya, Khwaileh Tariq
doaj   +1 more source

Epidemiological patterns of hepatitis B virus (HBV) in highly endemic areas [PDF]

, 1996
This paper uses meta-analysis of published data and a deterministic mathematical model of hepatitis B virus (HBV) transmission to describe the patterns of HBV infection in high endemicity areas.
A. J. Hall, Anderson, Barin, C. J. O'Callaghan, D. J. Nokes, G. F. Medley, Gebreselassie, H. C. Whittle, Milne, Overby, Pearce, Pongpipat, Prozesky, Reniers, Schweitzer, Shiraki, Sobeslavsky, Sokal, Swenson, Tong, W. J. Edmunds   +20 more
core   +2 more sources