Results 181 to 190 of about 1,594,214 (312)

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

When Stones Begin: Age of Onset Reveals the Systemic Metabolic Nature of Nephrolithiasis. [PDF]

Res Rep Urol
Alrabadi A, Alshraideh BA, Almomani EY, Alkayed Y, Abu-Suaileek MH, Alsougier HA, Etoom SA, Qablan A, Alrabadi Z.   +8 more
europepmc   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Leukocytes Transcriptome Analysis of Genes Associated with Epilepsy Duration and Age of Onset. [PDF]

Mol Neurobiol
Sarangdhar MA, Zelano J.
europepmc   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Age at onset of Parkinson's disease modulates the sphingolipid-dopaminergic interplay in autonomic progression. [PDF]

NPJ Parkinsons Dis
Ye Z, Zhang S, Liu Z, Wang J, Li J, Yu X, Yuan X, Chen Z, Yuan Z, Yang Z, Huang S, Weng Y, Yang D.   +12 more
europepmc   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Predicting accumulation and age at onset of amyloid-β from genetic risk and resilience for Alzheimer's disease. [PDF]

EBioMedicine
O'Brien EK, Cox T, Fernandez S, Bourgeat P, Porter T, Goudey B, Doecke JD, Masters CL, Fripp J, Nho K, Villemagne VL, Cruchaga C, Rowe CC, Saykin AJ, Doré V, Laws SM.   +15 more
europepmc   +1 more source

The Relationship Between Age at Diabetes Onset and Clinical Outcomes in Newly Diagnosed Type 2 Diabetes: A Real-World Two-Center Study

Mengdie Chen,1 Ping Feng,1 Yao Liang,2 Xun Ye,3 Yiyun Wang,2 Qiao Liu,1 Chaoyin Lu,1 Qidong Zheng,2 Lijing Wu2 1Department of Endocrinology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, People’s Republic of China ...
Wu L, Chen M, Liang Y, Lu C, Liu Q, Zheng Q, Wang Y, Ye X, Feng P   +8 more
core  

Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study

, 2005
Juvenile rheumatoid arthritis (JRA) comprises a group of chronic systemic inflammatory disorders that primarily affect joints and can cause long-term disability.
Woo, P, Colbert, RA, Bukulmez, H, Thompson, SD, Twine, NA, Tsoras, M, Glass, DN, Olson, JM, Fife, M, Elston, RC   +9 more
core