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Age at Onset and Causes of Disease

Perspectives in Biology and Medicine, 1986
We know a good deal about the origins and pathogenesis of monogenic diseases, but we still know too little of how and what the genes contribute to multifactorial diseases. We seldom know which loci are involved, or which alleles inhabit them. Nor can we say how the effects of each gene modify those of others in the deranged homeostasis that constitutes
B, Childs, C R, Scriver
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Age of onset in hereditary lymphedema

The Journal of Pediatrics, 2003
To characterize age of onset patterns and penetrance in hereditary lymphedema, including differences caused by sex and genetic heterogeneity.Kaplan-Meier analysis of three family cohorts with autosomal dominant lymphedema: (1) five families with unique mutations in FLT4, (2) 16 families with unique mutations in FOXC2, and (3) 77 families with no ...
Kara L, Levinson   +5 more
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Schizophrenia: age at disease onset

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2014
Until now the problem of the typical age of schizophrenia onset has been actively discussing in the world literature. Though there are more and more publications, which mention the growth in the number of cases with late-onset and very-late-onset of the disease, a conviction that schizophrenia is the illness of teenagers or young people is still exists.
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AGE OF ONSET AND TYPE OF LEUKAEMIA

The Lancet, 1989
Facteurs de risques exogenes et concernant l'hote: irradiation, mutagenes, facteurs lies a l ...
A, Butturini, R P, Gale
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Restraint and age at onset of obesity

Addictive Behaviors, 1981
Abstract Dietary restraint in 30 obese females was examined in relation to age at onset of obesity. Juvenile-onset obese individuals were found to experience significantly more restraint in their eating behavior than adult-onset obese individuals, based on responses to Herman's revised Restraint Questionnaire.
P M, O'Neil   +5 more
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ONSET OF PEPTIC ULCER IN THE AGED

Journal of the American Medical Association, 1948
In a previous report of 408 cases of bleeding peptic ulcer,1it was observed that 56 or 13.7 per cent were in patients over the age of 60 years. A review of the 56 cases revealed that in 25 of them the first symptoms of ulcer occurred after the fifth decade.
H A, RAFSKY, M, WEINGARTEN, C I, KRIEGER
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Age of Onset of Lactose Malabsorption

Pediatrics, 1980
The Committee on Nutrition, American Academy of Pediatrics, understandably focuses on American ethnic groups in the section of their article1 dealing with studies on lactose intolerance. Their conclusions bear out the earlier one by Bayless et al2 that although precise data are lacking on age of onset of lactose malabsorption (LM) among children in the
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Age at Smoking Onset and the Onset of Depression and Anxiety Disorders

Nicotine & Tobacco Research, 2011
Smoking is a known risk indicator for depression and some of the anxiety disorders. No data are available on the role of age at smoking onset in the development of depression and anxiety disorders. We examined the association of smoking onset age on the onset age of depression and anxiety disorders.Participants of the Netherlands Study of Depression ...
Jamal, M.   +3 more
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Determinants of onset age in Friedreich’s ataxia

Journal of Neurology, 1998
We studied the factors that might influence onset age in Friedreich's ataxia in 41 cases (20 male, 21 female) homozygous for GAA expansion on the first intron of X25 gene. Patients came from 18 multiplex families (13 couples, 5 triplets). Mean age (SD) was 18.1 (8.9) years and did not differ by gender.
De Michele G   +7 more
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The onset age of periodontal destruction

Journal of Clinical Periodontology, 1991
Abstract. In the present paper, the onset age of periodontal destruction is discussed. Results of epidemiological studies have shown that with increasing age, the prevalence of periodontitis in a population increases. Data show that after the age of 40 years, the % of the population affected by periodontitis remains rather constant.
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