Results 51 to 60 of about 2,514,827 (314)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Prevalência de fragilidade em uma população de longevos na região Sul do Brasil

Saúde em Debate
RESUMO Objetiva investigar a prevalência de fragilidade em uma população de longevos. Estudo observacional e transversal com idosos acima de 80 anos de um município da região Sul do Brasil.
Taís Elizabete Manfio Liberalesso, Fernanda Dallazen, Vanessa Adelina Casali Bandeira, Evelise Moraes Berlezi   +3 more
doaj   +1 more source

Factors associated with temporomandibular dysfunction in the elderly: an integrative literature review

Revista Brasileira de Geriatria e Gerontologia, 2019
Objective: To identify the factors associated with temporomandibular dysfunction among elderly persons. Method: An integrative literature review was carried out, evaluated by scientific publications indexed in five databases: MEDLINE/PubMed, SCOPUS, WEB
Patrícia Fernanda Faccio, Maria Angélica Bezerra dos Santos, Taís Arcanjo Maropo da Silva, Eduarda Correia Moretti, Maria das Graças Wanderley de Sales Coriolano, Carla Cabral dos Santos Accioly Lins   +5 more
doaj   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

PENGARUH WAKTU PENGENALAN PERTAMA SUSU FORMULA TERHADAP KEJADIAN GIZI LEBIH PADA BAYI USIA 11 - 12 BULAN [PDF]

, 2004
Pengenalan susu formula kepada bayi merupakan masalah yang saat ini mulai banyak timbul di Indonesia. Memberikan susu formula kepada bayi dianggap lebih bergengsi dan lebih praktis dari pada memberikan ASI kepada bayi. Kandungan zat gizi susu formula dan
NUGRAHANINGSIH, PRAMA
core  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Central nervous system relapse in patients over 80 years with diffuse large B‐cell lymphoma: an analysis of two LYSA studies

Cancer Medicine, 2018
CNS relapse is reported in 2–5% of diffuse large B‐cell lymphoma (DLBCL) patients, dramatically decreasing overall survival (OS). Very few studies address incidence and risk factors of CNS relapse in very elderly patients, a challenging population to ...
Aurélie Cabannes‐Hamy, Frederic Peyrade, Fabrice Jardin, Jean‐François Emile, Vincent Delwail, Nicolas Mounier, Corinne Haioun, Aurore Perrot, Olivier Fitoussi, Diane Lara, Richard Delarue, Marc André, Fritz Offner, Hervé Ghesquières, Laurent Pascal, Carole Soussain, Julien Lazarovici, Jean‐Marc Schiano, Philippe Gaulard, Hervé Tilly, Catherine Thieblemont, the LYSA, the lymphoma study association   +22 more
doaj   +1 more source

Safety of Percutaneous Endoscopic Gastrostomy Tubes in Centenarian Patients [PDF]

Clinical Endoscopy, 2018
Background/Aims Percutaneous endoscopic gastrostomy (PEG) is a relatively safe procedure; however, no study has evaluated the safety of PEG tube placement in patients over the age of 100 years.
Zain A Sobani, Kevin Tin, Steven Guttmann, Anna A Abbasi, Ira Mayer, Yuriy Tsirlin   +5 more
doaj   +1 more source

Dying in long-term care facilities in Europe : the PACE epidemiological study of deceased residents in six countries [PDF]

, 2019
Background: By 2030, 30% of the European population will be aged 60 or over and those aged 80 and above will be the fastest growing cohort. An increasing number of people will die at an advanced age with multiple chronic diseases.
Deliens, Luc, Froggatt, Katherine, Gambassi, Giovanni, Honinx, Elisabeth, Kylänen, Marika, Onwuteaka-Philipsen, Bregje, PACE, on behalf of, Piers, Ruth, Smets, Tinne, Szczerbińska, Katarzyna, Van den Block, Lieve, Van Den Noortgate, Nele, van Dop, Nanja   +12 more
core   +4 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source