Results 111 to 120 of about 1,568,668 (248)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
What do you expect at your age? A Help the Aged conference on age discrimination, 17 March, 2003
, 2003 Title from coverSIGLEAvailable from British Library Document Supply Centre- DSC:m03/36546 / BLDSC - British Library Document Supply CentreGBUnited ...
Help the Aged (United Kingdom)
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Nursing OpenAim To explore the experiences and perspectives of clinical facilitators supervising first‐year nursing students in nursing homes. Design The qualitative clinical facilitator interview component of a two‐stage sequential mixed methods study exploring the
Jo‐Anne Rayner +3 more
doaj +1 more source
Journal of the Royal College of Physicians of Edinburgh, 1999 MacLennan, W. J. +1 more
openaire +3 more sources
Health Care Rationing in the Aged: Ethical and Clinical Perspectives
, 1999 This article provides an ethical analysis of the question of whether aged patients' access to health care should be less than, the same or greater than, the access younger patients enjoy, when economic resources are limited.
Howe, Edmund G. +1 more
core +1 more source