Results 221 to 230 of about 7,720,905 (351)

Reevaluating the Little Ice Age: Novel insights from oceanic and terrestrial records on unexpected warm winters

, 2023
Huimin Guo, Wenfeng Deng, Xuefei Chen, Jian‐xin Zhao, Gangjian Wei   +4 more
openalex   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Single-Cell Profiling Reveals RAB13⁺ Endothelial Cells and Profibrotic Mesenchymal Cells in Aged Human Bone Marrow. [PDF]

Aging Cell
Cenzano I, Cócera M, Lopez-Perez AR, Campos-Dopazo L, Ruiz J, Sancho I, Martin-Uriz PS, Aguirre-Ruiz P, Sarvide S, Vilas-Zornoza A, Ripalda-Cemborain P, Alignani D, Lopez A, Barrios MM, Agreda DQ, Ye J, Lehmann R, Sudupe L, Abengozar-Muela M, Lopez-Janeiro Á, Tamariz-Amador LE, Muiños-López E, Saez B, Tegner J, Calvo IA, Gomez-Cabrero D, Prosper F.   +26 more
europepmc   +1 more source

Modeling of Water Age in the Drinking Water Distribution System of Trondheim Kommune

, 2020
Jon Kristian Rakstang
openalex   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

"Steak Dry Aging": An Innovative Approach to Producing High-Yield, High-Quality Dry-Aged Beef. [PDF]

J Food Sci
Dos Santos JC, Guimarães AS, Bueno LO, Carmo LRD, da Silveira MCT, Ramos ALS, Lopes LS, Ramos EM.   +7 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Optimizing cohort criteria for multi-country analysis of women experiencing menopause in administrative databases. [PDF]

BMC Med Res Methodol
Banks V, Brash J, Caetano C, Dinkel-Keuthage C, Herrera R, Janssenswillen C, Saadedine M, Schoof N, Moeller C.   +8 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source