Results 51 to 60 of about 4,094,798 (294)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Practice points for lymphoedema care in low- and middle- income countries developed by nominal group technique

BMC Health Services Research, 2023
Background Lymphoedema is a common, distressing, and debilitating condition affecting more than 200 million people globally. There is a small body of evidence to guide lymphoedema care which underpins several lymphoedema clinical practice guidelines ...
Eric Torgbenu, Tim Luckett, Mark Buhagiar, Jane L. Phillips   +3 more
doaj   +1 more source

The relationship between sleep and physical activity in nonagenarians and centenarians

Geriatrics, Gerontology and Aging, 2022
OBJECTIVE: Since the relationship between physical activity and sleep quality has been poorly studied in nonagenarians and centenarians, this study sought to relate the sleep quality and physical activity in this age group.
Francielle Bonett Aguirre, Antonia Angeli Gazola, Victória Albino Furlanetto Araujo, Ângelo José Gonçalves Bós   +3 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

What is Aging? [PDF]

Frontiers in Genetics, 2012
In 1991, the book Evolutionary Biology of Aging offered the following definition of aging: a persistent decline in the age-specific fitness components of an organism due to internal physiological deterioration (Rose, 1991). This definition has since been used by others a number of times.
Rose, Michael R, Flatt, Thomas, Graves, Joseph L, Greer, Lee F, Martinez, Daniel E, Matos, Margarida, Mueller, Laurence D, Reis, Robert J Shmookler, Shahrestani, Parvin   +8 more
openaire   +7 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

LncRNA MAGI2-AS3 promotes the progression of atherosclerosis by sponging miR-525-5p

Journal of Cardiothoracic Surgery
Background Increasing evidence showed that lncRNAs are involved in the procession of atherosclerosis (AS). This study detected MAGI2-AS3 expression in the serum of AS patients and further investigated the mechanism of MAGI2-AS3 in AS.
Lingfeng Zhu, Chan Yan
doaj   +1 more source

Improving care for cancer-related and other forms of lymphoedema in low- and middle-income countries: a qualitative study

BMC Health Services Research, 2022
Background Lymphoedema is a common, distressing and debilitating condition that can be related to cancer and its treatment or other conditions. Little is known about current practices in the diagnosis, assessment and management of lymphoedema in low- and
Eric Torgbenu, Tim Luckett, Mark Buhagiar, Cecilia Mauricio Requena, Jane L. Phillips   +4 more
doaj   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley   +1 more source