Results 51 to 60 of about 12,169,981 (313)

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

Nature Network Boston, 2019
An aged circulatory environment can activate microglia, reduce neural precursor cell activity and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate at least some of these effects. We observe that BECs in the aged mouse
H. Yousef, C. Czupalla, Davis P. Lee, Michelle B. Chen, Ashley Burke, K. Zera, J. Zandstra, Elisabeth Berber, B. Lehallier, Vidhu K. Mathur, Ramesh Nair, L. Bonanno, Andrew C. Yang, T. Peterson, Husein Hadeiba, Taylor Merkel, Jakob Körbelin, M. Schwaninger, M. Buckwalter, S. Quake, E. Butcher, T. Wyss-Coray   +21 more
semanticscholar   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

Aging Cell, 2016
While reports suggest a single dose of senolytics may improve vasomotor function, the structural and functional impact of long‐term senolytic treatment is unknown.
Carolyn M. Roos, Bin Zhang, Allyson K. Palmer, M. Ogrodnik, T. Pirtskhalava, Nassir M. Thalji, Michael A. Hagler, D. Jurk, Leslie A. Smith, Grace Casaclang-Verzosa, Yi Zhu, M. Schafer, T. Tchkonia, J. Kirkland, Jordan D. Miller   +14 more
semanticscholar   +1 more source

Incorporating foot assessment in the comprehensive geriatric assessment

BMC Geriatrics, 2021
Background Foot problems are common in older adults and associated with poorer physical function, falls, frailty and reduced quality of life. Comprehensive Geriatric Assessment (CGA), a multidisciplinary process that is considered the gold standard of ...
Rebecca K. Iseli, Gregory Duncan, Elton K. Lee, Ellen Lewis, Andrea B. Maier   +4 more
doaj   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Practice points for lymphoedema care in low- and middle- income countries developed by nominal group technique

BMC Health Services Research, 2023
Background Lymphoedema is a common, distressing, and debilitating condition affecting more than 200 million people globally. There is a small body of evidence to guide lymphoedema care which underpins several lymphoedema clinical practice guidelines ...
Eric Torgbenu, Tim Luckett, Mark Buhagiar, Jane L. Phillips   +3 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice

Journal of Neuroscience, 2005
Aging causes changes in the hippocampus that may lead to cognitive decline in older adults. In young animals, exercise increases hippocampal neurogenesis and improves learning.
H. van Praag, T. Shubert, Chunmei Zhao, F. Gage   +3 more
semanticscholar   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

LncRNA MAGI2-AS3 promotes the progression of atherosclerosis by sponging miR-525-5p

Journal of Cardiothoracic Surgery
Background Increasing evidence showed that lncRNAs are involved in the procession of atherosclerosis (AS). This study detected MAGI2-AS3 expression in the serum of AS patients and further investigated the mechanism of MAGI2-AS3 in AS.
Lingfeng Zhu, Chan Yan
doaj   +1 more source