Results 61 to 70 of about 12,169,981 (313)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

Aging Cell, 2018
Microglia, the resident immune cell of the brain, can be eliminated via pharmacological inhibition of the colony‐stimulating factor 1 receptor (CSF1R).
M. Elmore, Lindsay A. Hohsfield, E. Kramár, Lilach Soreq, Rafael J. Lee, S. T. Pham, A. Najafi, Elizabeth E. Spangenberg, M. Wood, B. West, K. Green   +10 more
semanticscholar   +1 more source

Improving care for cancer-related and other forms of lymphoedema in low- and middle-income countries: a qualitative study

BMC Health Services Research, 2022
Background Lymphoedema is a common, distressing and debilitating condition that can be related to cancer and its treatment or other conditions. Little is known about current practices in the diagnosis, assessment and management of lymphoedema in low- and
Eric Torgbenu, Tim Luckett, Mark Buhagiar, Cecilia Mauricio Requena, Jane L. Phillips   +4 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Evolving mass spectra of the oxidized component of organic aerosol: results from aerosol mass spectrometer analyses of aged diesel emissions

, 2008
The species and chemistry responsible for secondary organic aerosol (SOA) formation remain highly uncertain. Laboratory studies of the oxidation of individual, high-flux SOA precursors do not lead to particles with mass spectra (MS) matching those of ...
A. Sage, E. A. Weitkamp, Allen L. Robinson, N. M. Donahue   +3 more
semanticscholar   +1 more source

Rehabilitation, reablement, and restorative care approaches in the aged care sector: a scoping review of systematic reviews

BMC Geriatrics
Background Ageing populations are set to drive up demand for aged care services, placing strain on economies funding social care systems. Rehabilitation, reablement, and restorative care approaches are essential to this demographic shift as they aim to ...
Claire Gough, Raechel A. Damarell, Janine Dizon, Paul D.S. Ross, Jennifer Tieman   +4 more
doaj   +1 more source

Caring for depression in the dying is complex and challenging – survey of palliative physicians

BMC Palliative Care, 2022
Background Depression is prevalent in people with very poor prognoses (days to weeks). Clinical practices and perceptions of palliative physicians towards depression care have not been characterised in this setting.
Wei Lee, Sungwon Chang, Michelle DiGiacomo, Brian Draper, Meera R. Agar, David C. Currow   +5 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Aged‐senescent cells contribute to impaired heart regeneration

bioRxiv, 2018
Aging leads to increased cellular senescence and is associated with decreased potency of tissue-specific stem/progenitor cells. Here we have done an extensive analysis of cardiac progenitor cells (CPCs) isolated from human subjects with cardiovascular ...
Fiona C Lewis-McDougall, P. Ruchaya, Eva Domenjo-Vila, Tze Shin Teoh, L. Prata, Beverley J. Cottle, J. Clark, P. Punjabi, Wael I Awad, D. Torella, T. Tchkonia, J. Kirkland, G. Ellison‐Hughes   +12 more
semanticscholar   +1 more source