Results 71 to 80 of about 12,169,981 (313)

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Psychotropic medications in older people in residential care facilities and associations with quality of life: a cross-sectional study

BMC Geriatrics, 2018
Background Psychotropic medications have been associated with many adverse outcomes in older people living in residential care. Home-like models of residential care may be preferable to traditional models of care and we hypothesized that this model may ...
Stephanie L. Harrison, Clare Bradley, Rachel Milte, Enwu Liu, Lisa Kouladjian O’Donnell, Sarah N. Hilmer, Maria Crotty   +6 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Psychiatric Co-occurring Symptoms and Disorders in Young, Middle-Aged, and Older Adults with Autism Spectrum Disorder

Journal of Autism and Developmental Disorders, 2016
Although psychiatric problems are less prevalent in old age within the general population, it is largely unknown whether this extends to individuals with autism spectrum disorders (ASD).
A. G. Lever, H. M. Geurts
semanticscholar   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

Frontiers in Immunology, 2017
Advanced age is associated with chronic low-grade inflammation, which is usually referred to as inflammaging. Elderly are also known to have an altered gut microbiota composition.
F. Fransen, A. V. Van Beek, T. Borghuis, S. E. Aidy, F. Hugenholtz, Christa E. van der Gaast – de Jongh, H. Savelkoul, M. D. de Jonge, M. Boekschoten, H. Smidt, M. Faas, P. de Vos   +11 more
semanticscholar   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Nature, 2016
Cancer is a disease of ageing. Clinically, aged cancer patients tend to have a poorer prognosis than young. This may be due to accumulated cellular damage, decreases in adaptive immunity, and chronic inflammation.
A. Kaur, Marie R. Webster, K. Marchbank, Reeti Behera, A. Ndoye, C. Kugel, Vanessa M. Dang, J. Appleton, M. O’Connell, P. Cheng, Alexander A. Valiga, Rachel Morissette, N. McDonnell, L. Ferrucci, A. Kossenkov, Katrina M. Meeth, Hsin-Yao Tang, Xiangfan Yin, W. Wood, E. Lehrmann, K. Becker, K. Flaherty, Dennie T. Frederick, J. Wargo, Z. Cooper, M. Tetzlaff, C. Hudgens, K. Aird, Rugang Zhang, Xiaowei Xu, Qin Liu, E. Bartlett, G. Karakousis, Z. Eroglu, R. Lo, M. Chan, A. Menzies, G. Long, Douglas B. Johnson, J. Sosman, B. Schilling, D. Schadendorf, D. Speicher, M. Bosenberg, A. Ribas, A. Weeraratna   +45 more
semanticscholar   +1 more source

Interventions to delay functional decline in people with dementia: a systematic review of systematic reviews

BMJ Open, 2016
Objective To summarise existing systematic reviews that assess the effects of non-pharmacological, pharmacological and alternative therapies on activities of daily living (ADL) function in people with dementia.Design Overview of systematic reviews ...
Lindy Clemson, Kate Laver, Maria Crotty, Craig Whitehead, Suzanne Dyer   +4 more
doaj   +1 more source