Results 81 to 90 of about 14,824,921 (380)

Incorporating foot assessment in the comprehensive geriatric assessment

open access: yesBMC Geriatrics, 2021
Background Foot problems are common in older adults and associated with poorer physical function, falls, frailty and reduced quality of life. Comprehensive Geriatric Assessment (CGA), a multidisciplinary process that is considered the gold standard of ...
Rebecca K. Iseli   +4 more
doaj   +1 more source

The Hallmarks of Aging [PDF]

open access: yesCell, 2013
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases.
Carlos López-Otín   +4 more
openaire   +4 more sources

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Evolving mass spectra of the oxidized component of organic aerosol: results from aerosol mass spectrometer analyses of aged diesel emissions

open access: yes, 2008
The species and chemistry responsible for secondary organic aerosol (SOA) formation remain highly uncertain. Laboratory studies of the oxidation of individual, high-flux SOA precursors do not lead to particles with mass spectra (MS) matching those of ...
A. Sage   +3 more
semanticscholar   +1 more source

Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice

open access: yesJournal of Neuroscience, 2005
Aging causes changes in the hippocampus that may lead to cognitive decline in older adults. In young animals, exercise increases hippocampal neurogenesis and improves learning.
H. van Praag   +3 more
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

open access: yesNature Network Boston, 2019
An aged circulatory environment can activate microglia, reduce neural precursor cell activity and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate at least some of these effects. We observe that BECs in the aged mouse
H. Yousef   +21 more
semanticscholar   +1 more source

GABRA2 and Alcohol Dependence in College-Aged Students [PDF]

open access: yes, 2020
GABRA2 and Alcohol Dependence in College-aged Students Abaiz Chaudhri, Depts. of Biology and Chemistry, with Dr. Amy Adkins and Dr. Sally Kuo, Dept. of Psychology Problematic alcohol use and associated consequences is a major problem in college-aged ...
Chaudhri, Abaiz
core   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

open access: yesFEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere   +5 more
wiley   +1 more source

LncRNA MAGI2-AS3 promotes the progression of atherosclerosis by sponging miR-525-5p

open access: yesJournal of Cardiothoracic Surgery
Background Increasing evidence showed that lncRNAs are involved in the procession of atherosclerosis (AS). This study detected MAGI2-AS3 expression in the serum of AS patients and further investigated the mechanism of MAGI2-AS3 in AS.
Lingfeng Zhu, Chan Yan
doaj   +1 more source

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