Results 171 to 180 of about 2,393,425 (335)

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

No Survival Benefit in Octogenarians and Nonagenarians with Extended Hemodialysis Treatment Time. [PDF]

, 2018
BackgroundThe population of elderly end-stage renal disease patients initiating dialysis is rapidly growing. Although longer treatment is supposed to benefit for hemodialysis (HD) patients through more solute clearance and slower fluid removal, it is not
Chang, Tae Ik, Choi, Soo Jeong, Kalantar-Zadeh, Kamyar, Ko, Gang Jee, Kovesdy, Csaba P, Obi, Yoshitsugu, Rhee, Connie M, Soohoo, Melissa, Streja, Elani   +8 more
core  

Survey of 726 geriatric anesthesia cases of the age over 80 years.

, 1990
Tamie Yorimitsu, Shigeru KUNIYOSHI, Kiyoshi Chinen   +2 more
openalex   +2 more sources

Share of the population aged 65 and over and 80 and over, 2019 and 2050 [PDF]

, 2021

openalex   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Bone Density Status and Vitamin D and Calcium Concentrations in Pregnant and Non-Pregnant Women [PDF]

, 2016
Background: The aim of this study was to analyse differences in bone density and vitamin D and calcium concentrations between pregnant and non-pregnant women. Methods: This was an analytical, cross-sectional study of women aged 30 years or over, residing
Adriani, M. (Merryana), Setiarsih, D. (Dini), Wirjatmadi, B. (Bambang)   +2 more
core  

A case involving a bovine aortic arch contributing to blunt thoracic aortic injury of triple rupture close to the pericardial reflection

Trauma Case Reports
A blunt thoracic aortic injury is a fatal condition that often requires emergency surgery. Although injuries to the aortic isthmus are common in trauma patients, the proximal aortic arch often remains intact.
Takuma Aoki, Hidetoshi Oka, Naohiko Oki, Hirofumi Kasahara   +3 more
doaj  

Risk factors for postoperative pneumonia in older adults aged ≥ 80 years with gastric cancer

BMC Cancer
Background In Japan, the proportion of elderly gastric cancer patients is increasing. Although surgery in patients aged ≥ 80 years is relatively safe, postoperative pneumonia often occurs, reducing quality of life and being fatal.
Shunji Endo, Masaharu Higashida, Yoshinori Fujiwara, Kei Furuya, Shuya Yano, Toshimasa Okada, Kazuhiko Yoshimatsu, Tomio Ueno   +7 more
doaj   +1 more source

An Analysis of Postoperative Complications after Abdominal Surgery in Patients over 80 years of Age

, 1999
Ryouichi Tomita, Shigeru Fujisaki, Katsuhisa Tanjoh, Masahiko Shibata, Masahiro Fukuzawa   +4 more
openalex   +2 more sources

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source