Results 161 to 170 of about 107,054 (218)
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court +3 more
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
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The Journal of General Psychology
Agency is action aimed at goals selected by an agent. A deterministic world view leaves scant room for agency. To reconcile the arguments, we represent action as nested control systems, ranging from clearly deterministic to clearly volitional. Negative feedback minimizes deviations from setpoints (goals).
Peter R. Killeen +2 more
openaire +3 more sources
Agency is action aimed at goals selected by an agent. A deterministic world view leaves scant room for agency. To reconcile the arguments, we represent action as nested control systems, ranging from clearly deterministic to clearly volitional. Negative feedback minimizes deviations from setpoints (goals).
Peter R. Killeen +2 more
openaire +3 more sources
Econometrica, 1986
We extend the principal-agent framework with risk-neutral principals to situations in which several principals simultaneously and independently attempt to influence a common agent. We show that implementation is, in the aggregate, always efficient (cost-minimizing), and that noncooperative behavior induces an efficient (potentially second-best) action ...
Bernheim, B Douglas, Whinston, Michael D
openaire +1 more source
We extend the principal-agent framework with risk-neutral principals to situations in which several principals simultaneously and independently attempt to influence a common agent. We show that implementation is, in the aggregate, always efficient (cost-minimizing), and that noncooperative behavior induces an efficient (potentially second-best) action ...
Bernheim, B Douglas, Whinston, Michael D
openaire +1 more source
Proceedings of the Aristotelian Society, 2004
The definitive version is available at onlinelibrary.wiley.com ; Michael Bratman is rightly celebrated for his planning theory of intention. On this theory, intentions are characterized by the role they play as elements in larger plans, the dual purpose of which is to extend the influence of our deliberation into the future, and to enable the ...
Cullity, G., Gerrans, P.
openaire +2 more sources
The definitive version is available at onlinelibrary.wiley.com ; Michael Bratman is rightly celebrated for his planning theory of intention. On this theory, intentions are characterized by the role they play as elements in larger plans, the dual purpose of which is to extend the influence of our deliberation into the future, and to enable the ...
Cullity, G., Gerrans, P.
openaire +2 more sources
International Journal of Agent Technologies and Systems, 2013
Distributed Agency is the name of a conceptual framework for describing complex adaptive systems that this paper develops. To understand the complexity of the world in a holistic fashion, the field of Modeling and Simulation is currently lacking a common terminology in which different bodies of knowledge can communicate with each other in a general ...
Eugenio Dante Suarez +1 more
openaire +1 more source
Distributed Agency is the name of a conceptual framework for describing complex adaptive systems that this paper develops. To understand the complexity of the world in a holistic fashion, the field of Modeling and Simulation is currently lacking a common terminology in which different bodies of knowledge can communicate with each other in a general ...
Eugenio Dante Suarez +1 more
openaire +1 more source
Philosophy Compass, 2008
Abstract This paper provides an overview of recent discussions of the phenomenology of agency. By ‘the phenomenology of agency’ I mean those phenomenal states that are associated with first‐person agency. I call such states ‘agentive experiences’.
openaire +2 more sources
Abstract This paper provides an overview of recent discussions of the phenomenology of agency. By ‘the phenomenology of agency’ I mean those phenomenal states that are associated with first‐person agency. I call such states ‘agentive experiences’.
openaire +2 more sources