Results 191 to 200 of about 5,082,581 (316)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Evaluation of the Yes to Veg! Programme, a Food Systems Approach to Increase Vegetable Exposure and Agency in Pre-School Age Children: A Quasi-Experimental Study. [PDF]

Matern Child Nutr
Garcia AL, Zerr Z, Martin I, Parrett A.
europepmc   +1 more source

Metadata and Relational Architecture: Advancing Arrangement, Agency, and Access with New Methodology

, 2017
Jenna Morton‐Aiken, Jenna Morton-Aiken
openalex   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Does Accountability Require Agency? Comment on Responsibility and Accountability in the Algorithmic Society. [PDF]

Philos Technol
Vierkant T.
europepmc   +1 more source

Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the risk associated with the consumption of food supplements that contain creatine as an ingredient

Ángel J. Gutiérrez, Ángel Gil‐Izquierdo, Concepción María Aguilera García, Irene Bretón Lesmes, Gema Nieto, Sílvia Sánchez, María de Cortés Sánchez Mata   +6 more
openalex   +1 more source

Arguments delay setting up of European food agency

, 2001
Rory Watson
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Does out-of-hospital cardiac arrest survival differ by EMS agency type in the U.S.? Insights from the CARES registry. [PDF]

Resusc Plus
Nallamothu JL, Girotra S, Kennedy KF, Chan PS.   +3 more
europepmc   +1 more source

3 Social Space, Civil Society, and Dalit Agency in Twentieth-Century Kerala [PDF]

, 2016
P. Sanal Mohan
openalex   +1 more source