Results 211 to 220 of about 5,082,581 (316)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Evaluation of GABAergic and Glutamatergic Levels in the Dorsal Anterior Cingulate Cortex of Patients With Bipolar Disorder: A Cross-Sectional ¹H-MRS Study. [PDF]

Neuropsychopharmacol Rep
Moriyama S, Noda Y, Honda S, Edden RAE, Takahashi K, Saito K, Taniguchi K, Wada M, Tsugawa S, Tobari Y, Huh S, Nakane Y, Homma S, Matsui M, Koike S, Mimura M, Uchida H, Nakajima S.   +17 more
europepmc   +1 more source

Regeneration, investment, partnerships: a legacy [PDF]

, 2011
East Midlands Development Agency, EMDA
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

I see moving people: Expectations drive detection of biological motion in noisy point-light displays. [PDF]

Psychon Bull Rev
Szymanek P, Senderecka M, Hohol M.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Towards a Typology of Governance Mechanisms in Cross-sector Partnerships Based on Multiple Agency Theory

Jihye Kim, Jiwon Song, Dhruba Borah
openalex   +2 more sources

Opportunities at the International Atomic Energy Agency (IAEA)

, 2017
N. D. Rosenberg
openalex   +2 more sources

Nutrition and bone health projects funded by the UK Food Standards Agency: have they helped to inform public health policy? [PDF]

, 2007
Margaret Ashwell, Edwin M. Stone, John C. Mathers, Stephen Barnes, Juliet Compston, Roger M. Francis, Timothy J. Key, Kevin D. Cashman, Cyrus Cooper, Kay‐Tee Khaw, S. A. Lanham‐New, Helen Macdonald, Ann Prentice, Martin J. Shearer, Alison M. Stephen   +14 more
openalex   +1 more source