Results 81 to 90 of about 865,098 (341)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

open access: yesAdvanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Rural Alaska Corrections Plan (A Summary) [PDF]

open access: yes, 1980
Efforts to improve correctional services in the rural, predominantly Native communities of Alaska have been going on since before statehood. Complete implementation of plans developed by the Alaska Criminal Justice Planning Agency during the 1970s have ...
Angell, John E.
core  

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

open access: yesAdvanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo   +8 more
wiley   +1 more source

Conceptualising quality early childhood education: Learning from young children in Brazil and South Africa through creative and play‐based methods

open access: yesBritish Educational Research Journal, EarlyView., 2023
Abstract Early childhood has increasingly been acknowledged as a vital time for all children. Inclusive and quality education is part of the United Nations Sustainable Development Goals, with the further specification that all children have access to quality pre‐primary education.
Laura H. V. Wright   +8 more
wiley   +1 more source

Philosophizing the transfixed and the cybernetic

open access: yesEikasía
The article offers a philosophical reflection on today’s transfixed and cybernetic times, where technoscience, digitalization, and artificial intelligence (AI) deeply transform human experience amid a global polycrisis.
Andrés Merejo
doaj   +1 more source

Jakob Leupold’s Imaginary Automatic Anamorphic Devices of 1713 [PDF]

open access: yes, 2016
In 1713 the scientific instrument-maker Jakob Leupold published designs for three machines were the first attempt to design machinery with internal moving parts that replaced human agency in creating original images.
Gilbert, Bennett
core  

Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics

open access: yesAdvanced Science, EarlyView.
 . ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao   +3 more
wiley   +1 more source

Life as Self-Maintenance

open access: yesEthics in Progress
The article constructs the organism as a living being and – unlike an automaton – as an individual concerned with its own self-maintenance, endowed with intrinsic purposiveness, autoregulation, and with an agency of the self as well.
Dieter Wandschneider
doaj   +1 more source

The Impact of Empire on Native American Women and Mothers

open access: yes, 2014
No one doubts that the colonizing forces of the dominant, Euro-American culture have had an extreme and enduring impact on Native American cultures. However, the specific impact that empire has had on Native American women is a salient topic for research.
Yowan, Rebecca J.M.
core  

Dual-system theory and the role of consciousness in intentional action [PDF]

open access: yes, 2019
According to the standard view in philosophy, intentionality is the mark of genuine action. In psychology, human cognition and agency are now widely explained in terms of the workings of two distinct systems (or types of processes), and intentionality is
Schlosser, Markus E.
core  

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