Results 51 to 60 of about 2,376,871 (359)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Consumers and Agency Problems [PDF]
The Economic Journal, 2002 Consumers solve many agency problems, by pointing out when they believe that agents have made mistakes. I consider the role that consumers play in inducing efficient behaviour by agents. I distinguish cases where consumers have similar preferences to the principal, from those where they diverge.
openaire +1 more source
Conflicts and Financial Collapse: The Problem of Secondary-Management Agency Costs [PDF]
, 2009 Corporate governance scholarship has long focused on conflicts of interest between firms and their top executive officers. This Essay contends that increasing leverage and financial complexity make it important for scholars to also focus on conflicts of ...
Schwarcz, Steven L.
core +2 more sources
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Journal of Accounting and Investment, 2020 Research aims: Investment plays an essential role in the business growth of a company and the economy to develop more broadly. The role makes each institution implement investment targets and takes all actions to support the realization of investment ...
Ahmad Cahyo Nugroho +3 more
doaj +1 more source
AGENCY PROBLEM ANALYSIS FROM COMMITTEE AND OWNERSHIP STRUCTURES
Jurnal Riset Akuntansi Kontemporer, 2022 This study aims to determine the factors that influence the agency problem. A sample of 14 restaurant, hotel, and tourism sub-sector companies listed on the Indonesia Stock Exchange during the 2010–2019 period with a total of 140 observations was used as
Bayu Indra Setia +3 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Disciplinary effect of short selling: evidence from mergers and acquisitions
China Accounting and Finance ReviewUsing Regulation SHO's pilot program as a natural experiment, we study how removing short-selling constraints affects a firm's mergers and acquisitions (M&A). Design/methodology/approach: Difference-in-difference (DID) regressions.
Hai Lin, Chang Yu
doaj +1 more source
An Analysis of Venture Capital Contracts in Iran [PDF]
Iranian Journal of FinanceThis study aims to explore the dynamics of financial contracting in Iranian startups and high-tech companies, with a particular focus on the challenges posed by information asymmetry between investors and entrepreneurs.
Mehdi Sadaghiani +2 more
doaj +1 more source