Results 31 to 40 of about 62,591 (235)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Intermedia agenda setting en medios nacionales cubanos: casos Granma y Noticiero Nacional de Televisión. Estudio sobre temas no experienciales

open access: yesQuestion, 2016
La investigación sobre intermedia agenda setting es de reciente aplicación en Cuba. Los resultados encontrados sobre temáticas experienciales han expuesto los puntos de coincidencia y las divergencias de la teoría para el contexto nacional, el cual está ...
Viviana Muñiz Zúñiga   +1 more
doaj  

Nicht schon wieder

open access: yesMedienimpulse
kommt ...
Christian Swertz
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Agenda setting

open access: yes
Abstract From a global, comparative perspective, a court with the discretionary power to decide what it will decide, and this fact being publicly acknowledged and uncontroversial, are both far from the norm. Building on theoretical and empirical studies of courts in different jurisdictions, the authors show that mechanisms whereby courts
Michael Hill   +2 more
  +4 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Agendamento estratégico: política, justiça e comunicação no STF

open access: yesOrganicom
No livro "Da lei aos desejos: o agendamento estratégico do STF", publicado pela editora Amanuense, Grazielle Albuquerque acompanha a evolução da comunicação do Supremo Tribunal Federal no período entre a promulgação da Constituição Federal de 1988 e a ...
Cláudia Lemos
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Agenda-setting and Framing: details of the same theory?

open access: yesIntexto, 2012
In Agenda-setting and Framing literature there is a variety of research dedicated to examine the effects of communicative messages on the audience and its characteristics.
Graça Penha Nascimento Rossetto   +1 more
doaj  

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