Advanced Science, EarlyView.PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue +4 more
wiley +1 more source
Rethinking the Prevention of Cognitive Decline in Healthy Older Adults: The Motor-Cognitive Active Gamified Immersive Cultural (MAGIC) Exergames. [PDF]
JMIR AgingTemprado JJ.
europepmc +1 more source
Advanced Science, EarlyView.A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao +7 more
wiley +1 more source
From a shared origin to divergent frames: A computational analysis of media representations of Kampo Medicine and Traditional Chinese Medicine in Asahi Shimbun. [PDF]
PLoS OneChen X, Wang J, Liu X.
europepmc +1 more source
CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells
Advanced Science, EarlyView.AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu +6 more
wiley +1 more source
Mapping the Audiology and Speech Language Pathology (ASLP) curricula to NEP 2020: a document analysis of the RCI revised syllabus (2024). [PDF]
BMC Med EducVenkatraman K +2 more
europepmc +1 more source
Analytical Prediction of Critical Transitions in Oscillator Networks With Non‐Local Links
Advanced Science, EarlyView.An analytical framework reveals how global coupling, second‐harmonic strength, noise, and network structure govern oscillator‐based Ising dynamics. Spectral reduction predicts stability boundaries, while Fokker–Planck analysis captures one‐ to two‐cluster transitions and identifies conditions favoring low‐energy configurations.
Qiang Li +5 more
wiley +1 more source
The Toothbrushing Boost Toolbox: competence-building behavioral strategies for oral health. [PDF]
Front Public HealthAnand S +3 more
europepmc +1 more source
Mode‐Resolved Phonon Dynamics Under Chemical Pressure in SnTe Thermoelectrics
Advanced Science, EarlyView.Chemical pressure reshapes low‐energy optical phonons in SnTe, altering their dispersion and scattering with heat‐carrying acoustic modes. Positive and negative pressure states modify phonon frequencies and lifetimes in distinct ways, revealing how mode‐selective lattice perturbations regulate acoustic–optical interactions and suppress lattice thermal ...
Zhihao Li +7 more
wiley +1 more source