Results 201 to 210 of about 68,052 (258)

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

open access: yesAdvanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen   +7 more
wiley   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

open access: yesAdvanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang   +10 more
wiley   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

open access: yesAdvanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan   +10 more
wiley   +1 more source
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Representation and Agenda Setting

Policy Studies Journal, 2004
We develop a new approach to the study of representation based on agenda setting and attention allocation. We ask the fundamental question: do the policy priorities of the public and of the government correspond across time? To assess the policy priorities of the mass public, we have coded the Most Important Problem data from Gallup polls across the ...
BAUMGARTNER, Frank R., JONES, Bryan D.
openaire   +2 more sources

Setting the agenda

Nursing Standard, 1988
It's Sunday evening and I have just I come in after a full day's battle in my allotment. In a week's time I will be a hundred miles away in Brighton having to jolt my usual Sunday mental processes out of making decisions about when to plant the beetroot and instead decide between competing emergency resolutions for space on the Congress agenda.
openaire   +2 more sources

Constructivism and agenda setting

2016
Constructivism and agenda-setting have an intimate, but very often, implicit relationship. The aim of this chapter is to analyse this relationship more precisely. Starting from the central question in agenda-setting approaches, that is why do issues become a problem that political actors perceive to be necessary to address, this chapter presents ...
openaire   +3 more sources

Setting the Agenda

2014
This chapter looks at the events that immediately followed the terrorist attacks on 9/11 and how the neoconservatives immediately tried to shape the discourse by placing Iraq on the agenda. It shows the various institutional and public means through which this message was reinforced and decicion makers’ focus was directed on Iraq.
openaire   +1 more source

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