Results 81 to 90 of about 29,338,642 (259)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Agent-Based Simulation of Ecological Models
, 2004 Coastal lagoons ecosystems are very complex to model and its global behaviour its hard to simulate. This com-plexity is even greater if the simulation model includes the intelligent entities like decision-makers involved in the system. Typical ecological
António Pereira +2 more
core +1 more source
Modelling a potential zoonotic spillover event of H5N1 influenza
BMC Public HealthBackground Highly Pathogenic Avian Influenza (HPAI) is a prominent candidate for a future human pandemic arising from a zoonotic spillover event. Its best-known subtype is H5N1, with South- or South-East Asia a likely location for an initial outbreak ...
Philip Cherian, Gautam I. Menon
doaj +1 more source
ISPRS International Journal of Geo-InformationThe differential transmission of COVID-19 depending on the socio-economic status of a neighborhood is well established. For example, several studies have shown that COVID-19 transmission was higher in poorer and denser neighborhoods than in wealthier ...
Molly French +4 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Errors and Artefacts in Agent-Based Modelling [PDF]
The objectives of this paper are to define and classify different types of errors and artefacts that can appear in the process of developing an agent-based model, and to propose activities aimed at avoiding them during the model construction and testing ...
Luis R. Izquierdo +6 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A review of Multi-Agent Simulation Models in Agriculture [PDF]
Multi-Agent Simulation (MAS) models are intended to capture emergent properties of complex systems that are not amenable to equilibrium analysis. They are beginning to see some use for analysing agricultural systems. The paper reports on work in progress
Li, Frank Y. +5 more
core