Results 241 to 250 of about 11,927,890 (342)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Bayesian Calibration of Stochastic Agent Based Model via Random Forest. [PDF]

Stat Med
Robertson C, Safta C, Collier N, Ozik J, Ray J.   +4 more
europepmc   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Understanding Delayed Diabetes Diagnosis: An Agent-Based Model of Health-Seeking Behavior. [PDF]

Med Decis Making
Taghikhah FR, Jabbari A, Desouza KC, Malik A, Khorshidi HA.   +4 more
europepmc   +1 more source

An agent-based stock-flow consistent model of the sustainable transition in the energy sector

, 2018
L. Ponta, M. Raberto, A. Teglio, S. Cincotti   +3 more
semanticscholar   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Agent-based model of the human colon to investigate mechanisms of pathogen colonization resistance. [PDF]

Biophys J
Fletcher SJ, Ching C, Suprenant MP, Desai D, Zaman MH.   +4 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The Impact of Cooperation Under Climate Constraints: An Agent-Based Model for Exploring Paleolithic Behavioral Adaptations in the Inner Asian Mountain Corridor. [PDF]

J Archaeol Method Theory
Coto-Sarmiento M, Namen A, Varis A, Iovita R.   +3 more
europepmc   +1 more source

Coupling agent-based, cellular automata and logistic regression into a hybrid urban expansion model (HUEM)

, 2017
Ahmed M. Mustafa, M. Cools, Ismaïl Saadi, J. Teller   +3 more
semanticscholar   +1 more source